Disinhibition phenomenon in transmitter release: effect of β-endorphin on acetylcholine release

Research output: Contribution to journalArticle

Abstract

The release of acetylcholine from slices of the rat striatum has been studied in 2 groups of animals: untreated rats and rats pretreated by intracerebroventricular injections of 6-hydroxydopamine in doses sufficient partially or completely to destroy the nigrostriatal dopaminergic tract. The amount of acetylcholine released was much greater, both under resting conditions and in the presence of ouabain, from striatal slices from the latter group. It is suggested that β-endorphin, or some other enkephalin-like peptide present in the striatum, might moderate the dopaminergic inhibition of acetylcholine release by presynaptically inhibiting the release of dopamine. A disinhibition phenomenon of this type might play an important role in the modulation of neurochemical transmission.

Original languageEnglish
JournalNeuroscience Letters
Volume10
Issue numbersuppl. 1
Publication statusPublished - 1978

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Endorphins
Acetylcholine
Corpus Striatum
Enkephalins
Oxidopamine
Ouabain
Dopamine
Peptides
Injections

ASJC Scopus subject areas

  • Neuroscience(all)

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Disinhibition phenomenon in transmitter release : effect of β-endorphin on acetylcholine release. / Vízi, E.

In: Neuroscience Letters, Vol. 10, No. suppl. 1, 1978.

Research output: Contribution to journalArticle

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