Exokrin pancreasbetegségek és diabetes mellitus

Translated title of the contribution: Diseases of the exocrine pancreas and diabetes mellitus

Research output: Contribution to journalArticle

Abstract

Exocrine and endocrine pancreas constitutes close anatomical and functional links accordingly, any disease affecting one of these sectors will inevitably affect the other. Acute and chronic pancreatitis, pancreatic surgery, cystic fibrosis and pancreatic cancer are those pancreatic conditions that might cause diabetes mellitus. The development of diabetes greatly influences the prognosis and quality of life of patients with exocrine pancreatic diseases. The lack of glucagon and the impaired absorption of nutrients may cause life-threatening complications, such as hypoglycaemia, and the micro- and macrovascular complications may impair the organ functions. Diabetes mellitus is an independent risk factor of mortality in those with exocrine pancreatic diseases. Pancreatic diabetes is a distinct metabolic and clinical form of diabetes, requires special treatment. Diet and pancreatic enzyme replacement therapy may be sufficient in the early stages. Oral antidiabetic drugs are not recommended. If the diet proves inadequate to reach the glycaemic goals, regular insulin treatment is demanded. There are special impairments of the exocrine function and the pancreatic morphology at diabetic patients that resemble to chronic pancreatitis. Atrophy of the exocrine tissue may caused by the lack of trophic insulin. Hyperglycaemia can activate the stellate cells that lead to pancreatic fibrosis. The microangiopathy and neuropathy, as well as the lack of islet hormone action - responsible for the exocrine pancreas regulation - will cause further damage on the pancreas glandular tissue. In the event of a proven impairment of the pancreatic exocrine function in diabetes mellitus, pancreatic enzyme replacement therapy is recommended. This may improve the nutritional condition and decrease the metabolic instability.

Original languageHungarian
Pages (from-to)745-750
Number of pages6
JournalLege Artis Medicinae
Volume18
Issue number11
Publication statusPublished - Nov 2008

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Exocrine Pancreas
Enzyme Replacement Therapy
Pancreatic Diseases
Diabetes Mellitus
Chronic Pancreatitis
Insulin
Diet
Glucagon
Pancreatic Neoplasms
Islets of Langerhans
Hypoglycemia
Hypoglycemic Agents
Cystic Fibrosis
Hyperglycemia
Atrophy
Pancreas
Fibrosis
Quality of Life
Hormones
Food

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Exokrin pancreasbetegségek és diabetes mellitus. / Czakó, L.

In: Lege Artis Medicinae, Vol. 18, No. 11, 11.2008, p. 745-750.

Research output: Contribution to journalArticle

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