Disease expression in women with hereditary angioedema

Laurence Bouillet, Hilary Longhurst, Isabelle Boccon-Gibod, Konrad Bork, Christophe Bucher, Anette Bygum, Teresa Caballero, Christian Drouet, H. Farkas, Christian Massot, Erik W. Nielsen, Denise Ponard, Marco Cicardi

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Objective: Fluctuations in sex hormones can trigger angioedema attacks in women with hereditary angioedema. Combined oral contraceptive therapies, as well as pregnancy, can induce severe attacks. The course of angioedema may be very variable in different women. Study Design: Within the PREHAEAT project launched by the European Union, data on 150 postpubertal women with hereditary angioedema were collected in 8 countries, using a patient-based questionnaire. Results: Puberty worsened the disease for 62%. Combined oral contraceptives worsened the disease for 79%, whereas progestogen-only pills improved it for 64%. During pregnancies, 38% of women had more attacks, but 30% had fewer attacks. Vaginal delivery was usually uncomplicated. Attacks occurred within 48 hours in only 6% of cases. Those more severely affected during menses had more symptoms during pregnancies, suggesting a hormone-sensitive phenotype for some patients. Conclusion: The course of angioedema in women with C1 inhibitor deficiency is affected by physiologic hormonal changes; consequently, physicians should take these into account when advising on management.

Original languageEnglish
JournalAmerican Journal of Obstetrics and Gynecology
Volume199
Issue number5
DOIs
Publication statusPublished - Nov 2008

Fingerprint

Hereditary Angioedemas
Angioedema
Contraceptives, Oral, Combined
Pregnancy
Menstruation
Gonadal Steroid Hormones
Progestins
European Union
Puberty
Hormones
Physicians
Phenotype

Keywords

  • angioedema
  • estrogens
  • pregnancies
  • puberty

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Bouillet, L., Longhurst, H., Boccon-Gibod, I., Bork, K., Bucher, C., Bygum, A., ... Cicardi, M. (2008). Disease expression in women with hereditary angioedema. American Journal of Obstetrics and Gynecology, 199(5). https://doi.org/10.1016/j.ajog.2008.04.034

Disease expression in women with hereditary angioedema. / Bouillet, Laurence; Longhurst, Hilary; Boccon-Gibod, Isabelle; Bork, Konrad; Bucher, Christophe; Bygum, Anette; Caballero, Teresa; Drouet, Christian; Farkas, H.; Massot, Christian; Nielsen, Erik W.; Ponard, Denise; Cicardi, Marco.

In: American Journal of Obstetrics and Gynecology, Vol. 199, No. 5, 11.2008.

Research output: Contribution to journalArticle

Bouillet, L, Longhurst, H, Boccon-Gibod, I, Bork, K, Bucher, C, Bygum, A, Caballero, T, Drouet, C, Farkas, H, Massot, C, Nielsen, EW, Ponard, D & Cicardi, M 2008, 'Disease expression in women with hereditary angioedema', American Journal of Obstetrics and Gynecology, vol. 199, no. 5. https://doi.org/10.1016/j.ajog.2008.04.034
Bouillet L, Longhurst H, Boccon-Gibod I, Bork K, Bucher C, Bygum A et al. Disease expression in women with hereditary angioedema. American Journal of Obstetrics and Gynecology. 2008 Nov;199(5). https://doi.org/10.1016/j.ajog.2008.04.034
Bouillet, Laurence ; Longhurst, Hilary ; Boccon-Gibod, Isabelle ; Bork, Konrad ; Bucher, Christophe ; Bygum, Anette ; Caballero, Teresa ; Drouet, Christian ; Farkas, H. ; Massot, Christian ; Nielsen, Erik W. ; Ponard, Denise ; Cicardi, Marco. / Disease expression in women with hereditary angioedema. In: American Journal of Obstetrics and Gynecology. 2008 ; Vol. 199, No. 5.
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