Disease-Associated Qualitative and Quantitative Trait Loci in Proteoglycan-Induced Arthritis and Collagen-Induced Arthritis

Tibor T. Glant, V. A. Adarichev, A. B. Nesterovitch, S. Szántó, J. P. Oswald, J. J. Jacobs, G. Firneisz, J. Zhang, A. Finnegan, K. Mikecz

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Two autoimmune murine models-proteoglycan (aggrecan)-induced arthritis (PGIA) and collagen-induced arthritis (CIA)-were developed in parent strains, F1 and F2 hybrids of major histocompatibility complex (MHC)-matched (H-2 d) BALB/c × DBA/2 and MHC-unmatched (H-2d/H-2 q) BALB/c × DBA/1 intercrosses. The major goal of this comparative study was to identify disease (model)-specific (PGIA or CIA) and shared clinical and immunologic loci in 2 types of genetic intercrosses. Qualitative (binary/susceptibility) and quantitative (severity and onset) clinical trait loci were separated and analyzed independently or together with various pathophysiologic/immunologic traits, such as antigen-specific T- and B-cell responses and cytokine production. The major quantitative trait locus (QTL) was the MHC on chromosome 17, which was especially dominant in CIA. In addition, chromosomes 3, 5, 10, and X contained shared clinical loci in both models, and a total of 8 QTLs (clinical traits together with immunologic traits) were colocalized in PGIA and CIA.

Original languageEnglish
Pages (from-to)188-195
Number of pages8
JournalAmerican Journal of the Medical Sciences
Volume327
Issue number4
DOIs
Publication statusPublished - Apr 2004

Fingerprint

Experimental Arthritis
Quantitative Trait Loci
Proteoglycans
Major Histocompatibility Complex
Histocompatibility Antigen H-2D
Aggrecans
Dilatation and Curettage
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 3
Viral Tumor Antigens
B-Lymphocytes
Cytokines

Keywords

  • Arthritis
  • Collagen-induced arthritis
  • Genome screen
  • Proteoglycan-induced arthritis
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Disease-Associated Qualitative and Quantitative Trait Loci in Proteoglycan-Induced Arthritis and Collagen-Induced Arthritis. / Glant, Tibor T.; Adarichev, V. A.; Nesterovitch, A. B.; Szántó, S.; Oswald, J. P.; Jacobs, J. J.; Firneisz, G.; Zhang, J.; Finnegan, A.; Mikecz, K.

In: American Journal of the Medical Sciences, Vol. 327, No. 4, 04.2004, p. 188-195.

Research output: Contribution to journalArticle

Glant, Tibor T. ; Adarichev, V. A. ; Nesterovitch, A. B. ; Szántó, S. ; Oswald, J. P. ; Jacobs, J. J. ; Firneisz, G. ; Zhang, J. ; Finnegan, A. ; Mikecz, K. / Disease-Associated Qualitative and Quantitative Trait Loci in Proteoglycan-Induced Arthritis and Collagen-Induced Arthritis. In: American Journal of the Medical Sciences. 2004 ; Vol. 327, No. 4. pp. 188-195.
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