Discrimination of clinical stages in non-small cell lung cancer patients by serum HSP27 and HSP70: A multi-institutional case-control study

Matthias Zimmermann, Stefanie Nickl, Christopher Lambers, Stefan Hacker, Andreas Mitterbauer, Konrad Hoetzenecker, Anita Rozsas, G. Ostoros, Viktoria Laszlo, Helmut Hofbauer, Ferenc Renyi-Vamos, Walter Klepetko, B. Döme, Hendrik Jan Ankersmit

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Introduction: Lung cancer represents a major healthcare problem. Accordingly, there is an urgent need to identify serum biomarkers for early diagnosis of lung pathology. We have recently described that patients with manifest COPD evidence elevated levels of heat shock proteins (HSPs). Based on these data, we speculated whether HSPs are also increased in patients with diagnosed lung cancer. Methods: Serum levels of HSP27, phospho-HSP27 (pHSP27) and HSP70 in patients with non-small cell lung cancer (NSCLC) diagnosed at an early (stages I-II, n=37) or advanced (stages IIIA-IV, n=72) stage were determined by using ELISA. Healthy smokers (n=24), healthy never-smoker volunteers (n=33) and COPD patients (n=34) according to GOLD classification served as control population. Results: Serum levels of HSP27 were elevated in patients with NSCLC diagnosed at an early or advanced stage when compared with both healthy control groups (P

Original languageEnglish
Pages (from-to)1115-1120
Number of pages6
JournalClinica Chimica Acta
Volume413
Issue number13-14
DOIs
Publication statusPublished - Jul 11 2012

Fingerprint

Heat-Shock Proteins
Non-Small Cell Lung Carcinoma
Case-Control Studies
Cells
Biomarkers
Pathology
Serum
Chronic Obstructive Pulmonary Disease
Lung Neoplasms
Early Diagnosis
Volunteers
Enzyme-Linked Immunosorbent Assay
Delivery of Health Care
Lung
Control Groups
Population

Keywords

  • Biomarker
  • Heat shock protein 27
  • NSCLC

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Zimmermann, M., Nickl, S., Lambers, C., Hacker, S., Mitterbauer, A., Hoetzenecker, K., ... Ankersmit, H. J. (2012). Discrimination of clinical stages in non-small cell lung cancer patients by serum HSP27 and HSP70: A multi-institutional case-control study. Clinica Chimica Acta, 413(13-14), 1115-1120. https://doi.org/10.1016/j.cca.2012.03.008

Discrimination of clinical stages in non-small cell lung cancer patients by serum HSP27 and HSP70 : A multi-institutional case-control study. / Zimmermann, Matthias; Nickl, Stefanie; Lambers, Christopher; Hacker, Stefan; Mitterbauer, Andreas; Hoetzenecker, Konrad; Rozsas, Anita; Ostoros, G.; Laszlo, Viktoria; Hofbauer, Helmut; Renyi-Vamos, Ferenc; Klepetko, Walter; Döme, B.; Ankersmit, Hendrik Jan.

In: Clinica Chimica Acta, Vol. 413, No. 13-14, 11.07.2012, p. 1115-1120.

Research output: Contribution to journalArticle

Zimmermann, M, Nickl, S, Lambers, C, Hacker, S, Mitterbauer, A, Hoetzenecker, K, Rozsas, A, Ostoros, G, Laszlo, V, Hofbauer, H, Renyi-Vamos, F, Klepetko, W, Döme, B & Ankersmit, HJ 2012, 'Discrimination of clinical stages in non-small cell lung cancer patients by serum HSP27 and HSP70: A multi-institutional case-control study', Clinica Chimica Acta, vol. 413, no. 13-14, pp. 1115-1120. https://doi.org/10.1016/j.cca.2012.03.008
Zimmermann, Matthias ; Nickl, Stefanie ; Lambers, Christopher ; Hacker, Stefan ; Mitterbauer, Andreas ; Hoetzenecker, Konrad ; Rozsas, Anita ; Ostoros, G. ; Laszlo, Viktoria ; Hofbauer, Helmut ; Renyi-Vamos, Ferenc ; Klepetko, Walter ; Döme, B. ; Ankersmit, Hendrik Jan. / Discrimination of clinical stages in non-small cell lung cancer patients by serum HSP27 and HSP70 : A multi-institutional case-control study. In: Clinica Chimica Acta. 2012 ; Vol. 413, No. 13-14. pp. 1115-1120.
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