Discrete coding of stimulus value, reward expectation, and reward prediction error in the dorsal striatum

Kei Oyama, Yukina Tateyama, I. Hernádi, Philippe N. Tobler, Toshio Iijima, Ken Ichiro Tsutsui

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To investigate how the striatum integrates sensory information with reward information for behavioral guidance, we recorded single-unit activity in the dorsal striatum of head-fixed rats participating in a probabilistic Pavlovian conditioning task with auditory conditioned stimuli (CSs) in which reward probability was fixed for each CS but parametrically varied across CSs. We found that the activity of many neurons was linearly correlated with the reward probability indicated by the CSs. The recorded neurons could be classified according to their firing patterns into functional subtypes coding reward probability in different forms such as stimulus value, reward expectation, and reward prediction error. These results suggest that several functional subgroups of dorsal striatal neurons represent different kinds of information formed through extensive prior exposure to CS-reward contingencies.

Original languageEnglish
Pages (from-to)2600-2615
Number of pages16
JournalJournal of Neurophysiology
Volume114
Issue number5
DOIs
Publication statusPublished - Nov 6 2015

Fingerprint

Reward
Neurons
Corpus Striatum
Head

Keywords

  • Head-fixed rats
  • Pavlovian conditioning
  • Single-unit recording

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Discrete coding of stimulus value, reward expectation, and reward prediction error in the dorsal striatum. / Oyama, Kei; Tateyama, Yukina; Hernádi, I.; Tobler, Philippe N.; Iijima, Toshio; Tsutsui, Ken Ichiro.

In: Journal of Neurophysiology, Vol. 114, No. 5, 06.11.2015, p. 2600-2615.

Research output: Contribution to journalArticle

Oyama, Kei ; Tateyama, Yukina ; Hernádi, I. ; Tobler, Philippe N. ; Iijima, Toshio ; Tsutsui, Ken Ichiro. / Discrete coding of stimulus value, reward expectation, and reward prediction error in the dorsal striatum. In: Journal of Neurophysiology. 2015 ; Vol. 114, No. 5. pp. 2600-2615.
@article{33099aba1701485aaf1a97949ee8dd2f,
title = "Discrete coding of stimulus value, reward expectation, and reward prediction error in the dorsal striatum",
abstract = "To investigate how the striatum integrates sensory information with reward information for behavioral guidance, we recorded single-unit activity in the dorsal striatum of head-fixed rats participating in a probabilistic Pavlovian conditioning task with auditory conditioned stimuli (CSs) in which reward probability was fixed for each CS but parametrically varied across CSs. We found that the activity of many neurons was linearly correlated with the reward probability indicated by the CSs. The recorded neurons could be classified according to their firing patterns into functional subtypes coding reward probability in different forms such as stimulus value, reward expectation, and reward prediction error. These results suggest that several functional subgroups of dorsal striatal neurons represent different kinds of information formed through extensive prior exposure to CS-reward contingencies.",
keywords = "Head-fixed rats, Pavlovian conditioning, Single-unit recording",
author = "Kei Oyama and Yukina Tateyama and I. Hern{\'a}di and Tobler, {Philippe N.} and Toshio Iijima and Tsutsui, {Ken Ichiro}",
year = "2015",
month = "11",
day = "6",
doi = "10.1152/jn.00097.2015",
language = "English",
volume = "114",
pages = "2600--2615",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "5",

}

TY - JOUR

T1 - Discrete coding of stimulus value, reward expectation, and reward prediction error in the dorsal striatum

AU - Oyama, Kei

AU - Tateyama, Yukina

AU - Hernádi, I.

AU - Tobler, Philippe N.

AU - Iijima, Toshio

AU - Tsutsui, Ken Ichiro

PY - 2015/11/6

Y1 - 2015/11/6

N2 - To investigate how the striatum integrates sensory information with reward information for behavioral guidance, we recorded single-unit activity in the dorsal striatum of head-fixed rats participating in a probabilistic Pavlovian conditioning task with auditory conditioned stimuli (CSs) in which reward probability was fixed for each CS but parametrically varied across CSs. We found that the activity of many neurons was linearly correlated with the reward probability indicated by the CSs. The recorded neurons could be classified according to their firing patterns into functional subtypes coding reward probability in different forms such as stimulus value, reward expectation, and reward prediction error. These results suggest that several functional subgroups of dorsal striatal neurons represent different kinds of information formed through extensive prior exposure to CS-reward contingencies.

AB - To investigate how the striatum integrates sensory information with reward information for behavioral guidance, we recorded single-unit activity in the dorsal striatum of head-fixed rats participating in a probabilistic Pavlovian conditioning task with auditory conditioned stimuli (CSs) in which reward probability was fixed for each CS but parametrically varied across CSs. We found that the activity of many neurons was linearly correlated with the reward probability indicated by the CSs. The recorded neurons could be classified according to their firing patterns into functional subtypes coding reward probability in different forms such as stimulus value, reward expectation, and reward prediction error. These results suggest that several functional subgroups of dorsal striatal neurons represent different kinds of information formed through extensive prior exposure to CS-reward contingencies.

KW - Head-fixed rats

KW - Pavlovian conditioning

KW - Single-unit recording

UR - http://www.scopus.com/inward/record.url?scp=84946854528&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946854528&partnerID=8YFLogxK

U2 - 10.1152/jn.00097.2015

DO - 10.1152/jn.00097.2015

M3 - Article

C2 - 26378201

AN - SCOPUS:84946854528

VL - 114

SP - 2600

EP - 2615

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 5

ER -