Discovery of new anti-inflammatory agents

F. Fülöp, L. Lázár, Z. Szakonyi, Marjo Pihlavisto, Sakari Alaranta, Petri J. Vainio, Auni Juhakoski, Anne Marjamäki, David J. Smith

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We have synthesized a series of novel hydrazines and hydrazino alcohols that specifically inhibit vascular adhesion protein-1 (VAP-1), a human endothelial cell adhesion molecule with a well-documented role in inflammation. VAP-1 is a semicarbazide-sensitive amine oxidase (SSAO), and the enzyme activity has been demonstrated to have a role in VAP-1 function. An indane hydrazino alcohol was able to reduce clinical symptoms of inflammation in experimental arthritis in rodents and has the potential to be a novel anti-inflammatory drug.

Original languageEnglish
Pages (from-to)965-972
Number of pages8
JournalPure and Applied Chemistry
Volume76
Issue number5
Publication statusPublished - May 2004

Fingerprint

Anti-Inflammatory Agents
Adhesion
Proteins
Alcohols
Hydrazines
Amine Oxidase (Copper-Containing)
Hydrazine
Cell adhesion
Endothelial cells
Enzyme activity
Amines
Molecules
Pharmaceutical Preparations
Rodentia
Oxidoreductases
human ESAM protein

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Fülöp, F., Lázár, L., Szakonyi, Z., Pihlavisto, M., Alaranta, S., Vainio, P. J., ... Smith, D. J. (2004). Discovery of new anti-inflammatory agents. Pure and Applied Chemistry, 76(5), 965-972.

Discovery of new anti-inflammatory agents. / Fülöp, F.; Lázár, L.; Szakonyi, Z.; Pihlavisto, Marjo; Alaranta, Sakari; Vainio, Petri J.; Juhakoski, Auni; Marjamäki, Anne; Smith, David J.

In: Pure and Applied Chemistry, Vol. 76, No. 5, 05.2004, p. 965-972.

Research output: Contribution to journalArticle

Fülöp, F, Lázár, L, Szakonyi, Z, Pihlavisto, M, Alaranta, S, Vainio, PJ, Juhakoski, A, Marjamäki, A & Smith, DJ 2004, 'Discovery of new anti-inflammatory agents', Pure and Applied Chemistry, vol. 76, no. 5, pp. 965-972.
Fülöp F, Lázár L, Szakonyi Z, Pihlavisto M, Alaranta S, Vainio PJ et al. Discovery of new anti-inflammatory agents. Pure and Applied Chemistry. 2004 May;76(5):965-972.
Fülöp, F. ; Lázár, L. ; Szakonyi, Z. ; Pihlavisto, Marjo ; Alaranta, Sakari ; Vainio, Petri J. ; Juhakoski, Auni ; Marjamäki, Anne ; Smith, David J. / Discovery of new anti-inflammatory agents. In: Pure and Applied Chemistry. 2004 ; Vol. 76, No. 5. pp. 965-972.
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