Discovery of new anti-inflammatory agents

Ferenc Fülöp, László Lázár, Zsolt Szakonyi, Marjo Pihlavisto, Sakari Alaranta, Petri J. Vainio, Auni Juhakoski, Anne Marjamäki, David J. Smith

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We have synthesized a series of novel hydrazines and hydrazino alcohols that specifically inhibit vascular adhesion protein-1 (VAP-1), a human endothelial cell adhesion molecule with a well-documented role in inflammation. VAP-1 is a semicarbazide-sensitive amine oxidase (SSAO), and the enzyme activity has been demonstrated to have a role in VAP-1 function. An indane hydrazino alcohol was able to reduce clinical symptoms of inflammation in experimental arthritis in rodents and has the potential to be a novel anti-inflammatory drug.

Original languageEnglish
Pages (from-to)965-972
Number of pages8
JournalPure and Applied Chemistry
Volume76
Issue number5
DOIs
Publication statusPublished - May 2004

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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    Fülöp, F., Lázár, L., Szakonyi, Z., Pihlavisto, M., Alaranta, S., Vainio, P. J., Juhakoski, A., Marjamäki, A., & Smith, D. J. (2004). Discovery of new anti-inflammatory agents. Pure and Applied Chemistry, 76(5), 965-972. https://doi.org/10.1351/pac200476050965