Discovery of estrogen deficiency as common cancer risk factor for highly and moderately estrogen dependent organs

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Accumulation of non-smoker, non-drinker elderly postmenopausal female patients among smoking-associated oral cancer cases raised the plausible idea: estrogen deficiency maybe a cancer risk factor. On the other hand the extremely rare cases of young women with oral cancer regularly exhibited hormonal disorders, such as irregular menstrual cycles and infertility. Furthermore, in the history of middle-aged female oral cancer cases primary ovarian failure or complete hysterectomy were conspicuously frequent findings suggesting an estrogen deficient milieu. Also, there were many striking contradictions concerning the associations of female sexual steroids and cancer risk. Till now, breast and endometrial cancers were regarded as typically estrogen-induced tumors, particularly in post-menopausal cases. Conversely, unexplained beneficial anti-cancer effects of hormone-replacement therapy were reported against cancers at several sites even for tumors of highly hormone-responsive organs. Re-evaluation of the results of experimental and epidemiological studies, endeavoring to justify the carcinogenic capacity of estrogen, exhibited many shortcomings and controversies. Recent findings both on smoking associated and hormone related cancers added up to the same conversion; not estrogen but rather its deficiency might provoke cancer initiation. Thorough review of literary data justified that the exquisite regulatory capacity of estrogen and its surveillance on growth, development, differentiation, and metabolism are indispensable, whereas an estrogen-deficient milieu may induce a breakdown in gene-regulation. Recognition of the anticancer capacity of estrogen may provide new insights into the aetiology of malignancies and leads to new strategies for cancer prevention and cure.

Original languageEnglish
Title of host publicationEstrogen Prevention for Breast Cancer
PublisherNova Science Publishers, Inc.
Pages1-22
Number of pages22
ISBN (Print)9781624173783
Publication statusPublished - Jan 2013

Fingerprint

Estrogens
Neoplasms
Mouth Neoplasms
Hormones
Tumors
Smoking
Metabolism
Gene expression
Hormone Replacement Therapy
Endometrial Neoplasms
Menstrual Cycle
Hysterectomy
Growth and Development
Steroids
Infertility
Epidemiologic Studies
History
Breast Neoplasms
Genes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Suba, Z. (2013). Discovery of estrogen deficiency as common cancer risk factor for highly and moderately estrogen dependent organs. In Estrogen Prevention for Breast Cancer (pp. 1-22). Nova Science Publishers, Inc..

Discovery of estrogen deficiency as common cancer risk factor for highly and moderately estrogen dependent organs. / Suba, Z.

Estrogen Prevention for Breast Cancer. Nova Science Publishers, Inc., 2013. p. 1-22.

Research output: Chapter in Book/Report/Conference proceedingChapter

Suba, Z 2013, Discovery of estrogen deficiency as common cancer risk factor for highly and moderately estrogen dependent organs. in Estrogen Prevention for Breast Cancer. Nova Science Publishers, Inc., pp. 1-22.
Suba Z. Discovery of estrogen deficiency as common cancer risk factor for highly and moderately estrogen dependent organs. In Estrogen Prevention for Breast Cancer. Nova Science Publishers, Inc. 2013. p. 1-22
Suba, Z. / Discovery of estrogen deficiency as common cancer risk factor for highly and moderately estrogen dependent organs. Estrogen Prevention for Breast Cancer. Nova Science Publishers, Inc., 2013. pp. 1-22
@inbook{ad192909f2d042bca9b1b3c336c3b4a7,
title = "Discovery of estrogen deficiency as common cancer risk factor for highly and moderately estrogen dependent organs",
abstract = "Accumulation of non-smoker, non-drinker elderly postmenopausal female patients among smoking-associated oral cancer cases raised the plausible idea: estrogen deficiency maybe a cancer risk factor. On the other hand the extremely rare cases of young women with oral cancer regularly exhibited hormonal disorders, such as irregular menstrual cycles and infertility. Furthermore, in the history of middle-aged female oral cancer cases primary ovarian failure or complete hysterectomy were conspicuously frequent findings suggesting an estrogen deficient milieu. Also, there were many striking contradictions concerning the associations of female sexual steroids and cancer risk. Till now, breast and endometrial cancers were regarded as typically estrogen-induced tumors, particularly in post-menopausal cases. Conversely, unexplained beneficial anti-cancer effects of hormone-replacement therapy were reported against cancers at several sites even for tumors of highly hormone-responsive organs. Re-evaluation of the results of experimental and epidemiological studies, endeavoring to justify the carcinogenic capacity of estrogen, exhibited many shortcomings and controversies. Recent findings both on smoking associated and hormone related cancers added up to the same conversion; not estrogen but rather its deficiency might provoke cancer initiation. Thorough review of literary data justified that the exquisite regulatory capacity of estrogen and its surveillance on growth, development, differentiation, and metabolism are indispensable, whereas an estrogen-deficient milieu may induce a breakdown in gene-regulation. Recognition of the anticancer capacity of estrogen may provide new insights into the aetiology of malignancies and leads to new strategies for cancer prevention and cure.",
author = "Z. Suba",
year = "2013",
month = "1",
language = "English",
isbn = "9781624173783",
pages = "1--22",
booktitle = "Estrogen Prevention for Breast Cancer",
publisher = "Nova Science Publishers, Inc.",

}

TY - CHAP

T1 - Discovery of estrogen deficiency as common cancer risk factor for highly and moderately estrogen dependent organs

AU - Suba, Z.

PY - 2013/1

Y1 - 2013/1

N2 - Accumulation of non-smoker, non-drinker elderly postmenopausal female patients among smoking-associated oral cancer cases raised the plausible idea: estrogen deficiency maybe a cancer risk factor. On the other hand the extremely rare cases of young women with oral cancer regularly exhibited hormonal disorders, such as irregular menstrual cycles and infertility. Furthermore, in the history of middle-aged female oral cancer cases primary ovarian failure or complete hysterectomy were conspicuously frequent findings suggesting an estrogen deficient milieu. Also, there were many striking contradictions concerning the associations of female sexual steroids and cancer risk. Till now, breast and endometrial cancers were regarded as typically estrogen-induced tumors, particularly in post-menopausal cases. Conversely, unexplained beneficial anti-cancer effects of hormone-replacement therapy were reported against cancers at several sites even for tumors of highly hormone-responsive organs. Re-evaluation of the results of experimental and epidemiological studies, endeavoring to justify the carcinogenic capacity of estrogen, exhibited many shortcomings and controversies. Recent findings both on smoking associated and hormone related cancers added up to the same conversion; not estrogen but rather its deficiency might provoke cancer initiation. Thorough review of literary data justified that the exquisite regulatory capacity of estrogen and its surveillance on growth, development, differentiation, and metabolism are indispensable, whereas an estrogen-deficient milieu may induce a breakdown in gene-regulation. Recognition of the anticancer capacity of estrogen may provide new insights into the aetiology of malignancies and leads to new strategies for cancer prevention and cure.

AB - Accumulation of non-smoker, non-drinker elderly postmenopausal female patients among smoking-associated oral cancer cases raised the plausible idea: estrogen deficiency maybe a cancer risk factor. On the other hand the extremely rare cases of young women with oral cancer regularly exhibited hormonal disorders, such as irregular menstrual cycles and infertility. Furthermore, in the history of middle-aged female oral cancer cases primary ovarian failure or complete hysterectomy were conspicuously frequent findings suggesting an estrogen deficient milieu. Also, there were many striking contradictions concerning the associations of female sexual steroids and cancer risk. Till now, breast and endometrial cancers were regarded as typically estrogen-induced tumors, particularly in post-menopausal cases. Conversely, unexplained beneficial anti-cancer effects of hormone-replacement therapy were reported against cancers at several sites even for tumors of highly hormone-responsive organs. Re-evaluation of the results of experimental and epidemiological studies, endeavoring to justify the carcinogenic capacity of estrogen, exhibited many shortcomings and controversies. Recent findings both on smoking associated and hormone related cancers added up to the same conversion; not estrogen but rather its deficiency might provoke cancer initiation. Thorough review of literary data justified that the exquisite regulatory capacity of estrogen and its surveillance on growth, development, differentiation, and metabolism are indispensable, whereas an estrogen-deficient milieu may induce a breakdown in gene-regulation. Recognition of the anticancer capacity of estrogen may provide new insights into the aetiology of malignancies and leads to new strategies for cancer prevention and cure.

UR - http://www.scopus.com/inward/record.url?scp=84892206185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892206185&partnerID=8YFLogxK

M3 - Chapter

AN - SCOPUS:84892206185

SN - 9781624173783

SP - 1

EP - 22

BT - Estrogen Prevention for Breast Cancer

PB - Nova Science Publishers, Inc.

ER -