Discovery and significance of new human T-lymphotropic viruses: HTLV-3 and HTLV-4

P. Bagossi, Pálma Bander, Beáta Bozóki, J. Tőzsér

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Human T-lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) were discovered approximately 30 years ago and they are associated with various lymphoproliferative and neurological diseases. The estimated number of infected people is 10-20 million worldwide. In 2005, two new HTLV-1/HTLV-2-related viruses were detected, HTLV-3 and HTLV-4, from the same geographical area of Africa. In the last 4 years, their complete genomic sequences were determined and some of their characteristic features were studied in detail. These newly discovered retroviruses alongside their human (HTLV-1 and -2) and animal relatives (simian T-lymphotropic virus type 1-3) are reviewed. The potential risks associated with these viruses and the potential antiretroviral therapies are also discussed.

Original languageEnglish
Pages (from-to)1235-1249
Number of pages15
JournalExpert Review of Anti-Infective Therapy
Volume7
Issue number10
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Human T-lymphotropic virus 3
Human T-lymphotropic virus 1
Human T-lymphotropic virus 2
Simian T-lymphotropic virus 1
Satellite Viruses
Retroviridae
Viruses

Keywords

  • Adult T-cell leukemia
  • Antiretroviral therapy
  • Deltaretrovirus
  • HTLV-1-associated myelopathy
  • Human T-lymphotropic virus
  • Tropical spastic paraparesis

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Virology

Cite this

Discovery and significance of new human T-lymphotropic viruses : HTLV-3 and HTLV-4. / Bagossi, P.; Bander, Pálma; Bozóki, Beáta; Tőzsér, J.

In: Expert Review of Anti-Infective Therapy, Vol. 7, No. 10, 12.2009, p. 1235-1249.

Research output: Contribution to journalArticle

@article{0637a23aee5549b0922795db5c3d9560,
title = "Discovery and significance of new human T-lymphotropic viruses: HTLV-3 and HTLV-4",
abstract = "Human T-lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) were discovered approximately 30 years ago and they are associated with various lymphoproliferative and neurological diseases. The estimated number of infected people is 10-20 million worldwide. In 2005, two new HTLV-1/HTLV-2-related viruses were detected, HTLV-3 and HTLV-4, from the same geographical area of Africa. In the last 4 years, their complete genomic sequences were determined and some of their characteristic features were studied in detail. These newly discovered retroviruses alongside their human (HTLV-1 and -2) and animal relatives (simian T-lymphotropic virus type 1-3) are reviewed. The potential risks associated with these viruses and the potential antiretroviral therapies are also discussed.",
keywords = "Adult T-cell leukemia, Antiretroviral therapy, Deltaretrovirus, HTLV-1-associated myelopathy, Human T-lymphotropic virus, Tropical spastic paraparesis",
author = "P. Bagossi and P{\'a}lma Bander and Be{\'a}ta Boz{\'o}ki and J. Tőzs{\'e}r",
year = "2009",
month = "12",
doi = "10.1586/ERI.09.97",
language = "English",
volume = "7",
pages = "1235--1249",
journal = "Expert Review of Anti-Infective Therapy",
issn = "1478-7210",
publisher = "Expert Reviews Ltd.",
number = "10",

}

TY - JOUR

T1 - Discovery and significance of new human T-lymphotropic viruses

T2 - HTLV-3 and HTLV-4

AU - Bagossi, P.

AU - Bander, Pálma

AU - Bozóki, Beáta

AU - Tőzsér, J.

PY - 2009/12

Y1 - 2009/12

N2 - Human T-lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) were discovered approximately 30 years ago and they are associated with various lymphoproliferative and neurological diseases. The estimated number of infected people is 10-20 million worldwide. In 2005, two new HTLV-1/HTLV-2-related viruses were detected, HTLV-3 and HTLV-4, from the same geographical area of Africa. In the last 4 years, their complete genomic sequences were determined and some of their characteristic features were studied in detail. These newly discovered retroviruses alongside their human (HTLV-1 and -2) and animal relatives (simian T-lymphotropic virus type 1-3) are reviewed. The potential risks associated with these viruses and the potential antiretroviral therapies are also discussed.

AB - Human T-lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) were discovered approximately 30 years ago and they are associated with various lymphoproliferative and neurological diseases. The estimated number of infected people is 10-20 million worldwide. In 2005, two new HTLV-1/HTLV-2-related viruses were detected, HTLV-3 and HTLV-4, from the same geographical area of Africa. In the last 4 years, their complete genomic sequences were determined and some of their characteristic features were studied in detail. These newly discovered retroviruses alongside their human (HTLV-1 and -2) and animal relatives (simian T-lymphotropic virus type 1-3) are reviewed. The potential risks associated with these viruses and the potential antiretroviral therapies are also discussed.

KW - Adult T-cell leukemia

KW - Antiretroviral therapy

KW - Deltaretrovirus

KW - HTLV-1-associated myelopathy

KW - Human T-lymphotropic virus

KW - Tropical spastic paraparesis

UR - http://www.scopus.com/inward/record.url?scp=74249099310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74249099310&partnerID=8YFLogxK

U2 - 10.1586/ERI.09.97

DO - 10.1586/ERI.09.97

M3 - Article

C2 - 19968515

AN - SCOPUS:74249099310

VL - 7

SP - 1235

EP - 1249

JO - Expert Review of Anti-Infective Therapy

JF - Expert Review of Anti-Infective Therapy

SN - 1478-7210

IS - 10

ER -