Directed self-assembly of lipid nanotubes from inverted hexagonal structures

Kaori Sugihara, Mohamed Chami, I. Derényi, János Vörös, Tomaso Zambelli

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Conventional lipid-tube formation is based on either a tube phase of certain lipids or the shape transformation of lamellar structures by applying a point load. In the present study, lipid blocks in inverted hexagonal phase made of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) were shown to protrude lipid nanotubes upon a fluid-dynamic flow on polyelectrolyte-functionalized surfaces in physiological buffer solution. The outer diameter of the tubes is 19.1 ± 4.5 nm and their lengths are up to several hundred micrometers. The method described enables the alignment and patterning of lipid nanotubes into various (including curvy) shapes with a microfluidic system.

Original languageEnglish
Pages (from-to)6626-6632
Number of pages7
JournalACS Nano
Volume6
Issue number8
DOIs
Publication statusPublished - Aug 28 2012

Fingerprint

Self assembly
Nanotubes
Lipids
lipids
self assembly
nanotubes
tubes
Lamellar structures
fluid dynamics
Fluid dynamics
Polyelectrolytes
Microfluidics
micrometers
Buffers
buffers
alignment

Keywords

  • 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)
  • cryo-electron microscopy
  • directed self-assembly
  • inverted hexagonal structure
  • lipid nanotubes
  • microfluidic systems
  • polyelectrolytes

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

Cite this

Directed self-assembly of lipid nanotubes from inverted hexagonal structures. / Sugihara, Kaori; Chami, Mohamed; Derényi, I.; Vörös, János; Zambelli, Tomaso.

In: ACS Nano, Vol. 6, No. 8, 28.08.2012, p. 6626-6632.

Research output: Contribution to journalArticle

Sugihara, K, Chami, M, Derényi, I, Vörös, J & Zambelli, T 2012, 'Directed self-assembly of lipid nanotubes from inverted hexagonal structures', ACS Nano, vol. 6, no. 8, pp. 6626-6632. https://doi.org/10.1021/nn300557s
Sugihara, Kaori ; Chami, Mohamed ; Derényi, I. ; Vörös, János ; Zambelli, Tomaso. / Directed self-assembly of lipid nanotubes from inverted hexagonal structures. In: ACS Nano. 2012 ; Vol. 6, No. 8. pp. 6626-6632.
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