Directed self-assembly of lipid nanotubes from inverted hexagonal structures

Kaori Sugihara, Mohamed Chami, Imre Derényi, János Vörös, Tomaso Zambelli

Research output: Contribution to journalArticle

15 Citations (Scopus)


Conventional lipid-tube formation is based on either a tube phase of certain lipids or the shape transformation of lamellar structures by applying a point load. In the present study, lipid blocks in inverted hexagonal phase made of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) were shown to protrude lipid nanotubes upon a fluid-dynamic flow on polyelectrolyte-functionalized surfaces in physiological buffer solution. The outer diameter of the tubes is 19.1 ± 4.5 nm and their lengths are up to several hundred micrometers. The method described enables the alignment and patterning of lipid nanotubes into various (including curvy) shapes with a microfluidic system.

Original languageEnglish
Pages (from-to)6626-6632
Number of pages7
JournalACS Nano
Issue number8
Publication statusPublished - Aug 28 2012



  • 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)
  • cryo-electron microscopy
  • directed self-assembly
  • inverted hexagonal structure
  • lipid nanotubes
  • microfluidic systems
  • polyelectrolytes

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this