Direct solid-phase synthesis of the β-amyloid (1-42) peptide using controlled microwave heating

Bernadett Bacsa, Szilvia Bösze, C. Oliver Kappe

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

"Chemical Equation Presented" Standard linear Fmoc/t-Bu solid-phase synthesis of the 42-mer β-amyloid (1-42) peptide was achieved under controlled microwave conditions at 86 °C using inexpensive DIC/HOBt as coupling reagent on ChemMatrix resin. In order to avoid racemization of the sensitive amino acids, the coupling of the three His residues in the difficult peptide sequence was performed at room temperature. The desired peptide was obtained within 15 h overall processing time in high yield and purity (78 % crude yield).

Original languageEnglish
Pages (from-to)2103-2106
Number of pages4
JournalJournal of Organic Chemistry
Volume75
Issue number6
DOIs
Publication statusPublished - Mar 19 2010

ASJC Scopus subject areas

  • Organic Chemistry

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