Direct enzymatic route for the preparation of novel enantiomerically enriched hydroxylated β-amino ester stereoisomers

Eniko Forró, László Schönstein, Loránd Kiss, Alberto Vega-Peñaloza, Eusebio Juaristi, Ferenc Fülöp

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Enantiomerically enriched hydroxy-substituted β-amino esters have been synthesized through CAL-B-catalyzed enantioselective hydrolysis in organic media. Moderate to good enantiomeric excess values (ee ≥ 52%) were obtained when the CAL-Bcatalyzed reactions were performed in t-BuOMe, at 60 °C with 0.5 equiv. of added H2O as nucleophile.

Original languageEnglish
Pages (from-to)3998-4010
Number of pages13
JournalMolecules
Volume15
Issue number6
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Enantioselective
  • Enzyme
  • Hydrolysis
  • Hydroxylation
  • Organic solvent
  • Stereoisomer
  • β-Amino ester

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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