Direct effect of physiological doses of arginine vasopressin on the arterial wall in vivo

E. Monos, R. H. Cox, L. H. Peterson

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Effects of topically applied arginine vasopressin (VPA), in 100-150 μU/ml blood concentration, on external diameter (D) and on dynamic elastic modulus (E+) of surgically denervated common carotid (CC) and femoral (FA) arteries have been studied before and after hypophysectomy in anesthetized dogs. Changes in D, E+, and flow resistance (R) of the CC and FA vascular beds before and after removal of the pituitary were also determined. It was found that VPA elicited a substantial (max 21-26%) decrease in E+ and a smaller (max 5.9-6.9%) reduction in D of FA independent of the presence or absence of the pituitary gland. The VPA effect developed more rapidly after hypophysectomy than before. In the CC, VPA did not significantly affect values of E+. During the 1-h period after hypophysectomy, statistically significant decreases in E+-CC, E+-FA, and D-CC were observed, but D-FA did not change, although arterial pressure as well as R-FA and R-CC were diminished. These results give further support to physiological vascular actions of VPA and a possible role in short-term circulatory control. In large arteries, the effects of VPA also seem to be regionally differentiated.

Original languageEnglish
Pages (from-to)H167-H172
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume3
Issue number2
DOIs
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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