Direct and transgenerational effect of benzpyrene treatment at adolescent age on the uterine estrogen receptor and thymic glucocorticoid receptor of the adult rat

G. Csaba, Ágnes Inczefi-Gonda

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Hormonal imprinting develops perinatally at the first encounter between the maturing receptor and the target hormone, helping the normal accomplishment of receptor maturation. In the presence of hormone excess or foreign molecules able to bind to the maturing receptor, faulty imprinting takes place, which disturbs the normal receptor function for life. Earlier experiments demonstrated that the effect of faulty perinatal benzypyrene imprinting of the steroid hormone receptors is transmitted to the progeny generations. In certain organs which are maturing later (such as the uterus) imprinting can be executed at adolescence. In the present experiments pubertal benzpyrene imprinting caused a durable decrease in female's estrogen receptor density. The transgenerational effect of this type of imprinting was also studied. The pubertal imprinting of the parents was transgenerationally transmitted to the offspring generation in which - without further treatment - the density (B(max)) of the uterine estrogen receptors was significantly higher than that in the controls. There were measurable effects neither in the affinity (K(d)) of uterine estrogen receptors nor in the K(d) and B(max) of the male thymus glucocorticoid receptors. The experiments call attention to the profound and comprehensive imprinting effect of the environmental pollutant benzpyrene.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalActa Physiologica Hungarica
Volume86
Issue number1
Publication statusPublished - 1999

Fingerprint

Benzopyrenes
Glucocorticoid Receptors
Estrogen Receptors
Hormones
Therapeutics
Environmental Pollutants
Imprinting (Psychology)
Steroid Receptors
Thymus Gland
Uterus
Parents

Keywords

  • Adolescence
  • Aromatic hydrocarbon
  • Estrogen receptor
  • Glucocorticoid receptor
  • Hormonal imprinting
  • Steroid receptors
  • Transgenerational effect

ASJC Scopus subject areas

  • Physiology

Cite this

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abstract = "Hormonal imprinting develops perinatally at the first encounter between the maturing receptor and the target hormone, helping the normal accomplishment of receptor maturation. In the presence of hormone excess or foreign molecules able to bind to the maturing receptor, faulty imprinting takes place, which disturbs the normal receptor function for life. Earlier experiments demonstrated that the effect of faulty perinatal benzypyrene imprinting of the steroid hormone receptors is transmitted to the progeny generations. In certain organs which are maturing later (such as the uterus) imprinting can be executed at adolescence. In the present experiments pubertal benzpyrene imprinting caused a durable decrease in female's estrogen receptor density. The transgenerational effect of this type of imprinting was also studied. The pubertal imprinting of the parents was transgenerationally transmitted to the offspring generation in which - without further treatment - the density (B(max)) of the uterine estrogen receptors was significantly higher than that in the controls. There were measurable effects neither in the affinity (K(d)) of uterine estrogen receptors nor in the K(d) and B(max) of the male thymus glucocorticoid receptors. The experiments call attention to the profound and comprehensive imprinting effect of the environmental pollutant benzpyrene.",
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