Direct and indirect radical denitrations of intermediates in the synthesis of sorgolactone and its nuclear analogs

Katalin Mikló, Joseph Cs Jaszberenyi, István Kádas, Géza Árvai, L. Tőke

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Denitration of various important intermediates in the synthesis of sorgolactone and its analogs using radical chemistry on nitroketones or on the derived isocyanides is described. The nitro group is needed for the first step of the annellation process, the Michael addition of substituted nitroalkanes to cyclopentenones. Then it can be removed directly or after reduction to the amine or via the ketone obtained by the Nef-reaction.

Original languageEnglish
Pages (from-to)3491-3494
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number20
DOIs
Publication statusPublished - May 13 1996

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Denitrification
Cyanides
Ketones
Amines
cyclopentenone
sorgolactone

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Direct and indirect radical denitrations of intermediates in the synthesis of sorgolactone and its nuclear analogs. / Mikló, Katalin; Jaszberenyi, Joseph Cs; Kádas, István; Árvai, Géza; Tőke, L.

In: Tetrahedron Letters, Vol. 37, No. 20, 13.05.1996, p. 3491-3494.

Research output: Contribution to journalArticle

Mikló, Katalin ; Jaszberenyi, Joseph Cs ; Kádas, István ; Árvai, Géza ; Tőke, L. / Direct and indirect radical denitrations of intermediates in the synthesis of sorgolactone and its nuclear analogs. In: Tetrahedron Letters. 1996 ; Vol. 37, No. 20. pp. 3491-3494.
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