Dipeptides delay the onset of morphine withdrawal in the mouse

G. L. Kovacs, L. Szontagh, L. Balaspiri, G. Telegdy

Research output: Contribution to journalArticle


The effect of dipeptides was studied on naloxone-precipitated morphine withdrawal in the mouse. In accordance with previous data, s.c. treatment with Z-prolyl-D-leucine delayed the onset of withdrawal jumpings. Replacement of L-proline by L-glutamate or L-pyroglutamate resulted in dipeptides which were more potent in morphine withdrawal than was Z-prolyl-D-leucine.

Original languageEnglish
Pages (from-to)83-84
Number of pages2
JournalActa physiologica Hungarica
Issue number1
Publication statusPublished - Jan 1 1984


ASJC Scopus subject areas

  • Physiology (medical)

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