The effect of dipeptides was studied on naloxone-precipitated morphine withdrawal in the mouse. In accordance with previous data, s.c. treatment with Z-prolyl-D-leucine delayed the onset of withdrawal jumpings. Replacement of L-proline by L-glutamate or L-pyroglutamate resulted in dipeptides which were more potent in morphine withdrawal than was Z-prolyl-D-leucine.
|Number of pages||2|
|Journal||Acta physiologica Hungarica|
|Publication status||Published - Jan 1 1984|
ASJC Scopus subject areas
- Physiology (medical)