Diode laser based photoacoustic gas measuring instruments intended for medical research

Anna Szabó, A. Mohácsi, Péter Novák, Daniela Aladzic, Kinga Turzó, Zoltán Rakonczay, Gábor Erös, M. Borós, K. Nagy, Gábor Szabó

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Analysis of breath and gases emanated from skin can be used for early and non-invasive diagnosis of various kinds of diseases. Two portable, compact, photoacoustic spectroscopy based trace gas sensors were developed for the detection of methane emanated from skin and ammonia emanated from oral cavity. The light sources were distributed feedback diode lasers emitting at the absorption lines of ammonia and methane, at 1.53 μm and 1.65 μm, respectively. Photoacoustic method ensures high selectivity, therefore cross-sensitivity was negligible even with large amount of water vapor and carbon dioxide in the gas sample. In case of ammonia a preconcentration unit was used to achieve lower minimum detectable concentration. Gas sample from the oral cavity was drawn through a glass tube to the preconcentration unit that chemically bonded ammonia and released it when heated. The minimum detectable concentration of ammonia was 10 ppb for gas sample volume of 250 cm 3. For methane minimum detectable concentration of 0.25 ppm was found with 12 s integration time, and it was proved to be adequate for the detection of methane emanated from human skin and from mice. Instruments measuring methane and ammonia are currently installed at two medical research laboratories at University of Szeged and tested as instruments for non-invasive clinical trials. The aim of the measurements is to determine correlations between diseases or metabolic processes and emanated gases.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8427
DOIs
Publication statusPublished - 2012
EventBiophotonics: Photonic Solutions for Better Health Care III - Brussels, Belgium
Duration: Apr 16 2012Apr 19 2012

Other

OtherBiophotonics: Photonic Solutions for Better Health Care III
CountryBelgium
CityBrussels
Period4/16/124/19/12

Fingerprint

Semiconductor Lasers
Photoacoustic effect
Ammonia
Methane
Semiconductor lasers
Biomedical Research
ammonia
Gases
semiconductor lasers
methane
gases
Skin
Mouth
Photoacoustic spectroscopy
cavities
photoacoustic spectroscopy
Steam
Research laboratories
Chemical sensors
dioxides

Keywords

  • Ammonia
  • Medical research
  • Methane
  • Near infrared
  • Non-invasive
  • Oral cavity
  • Photoacoustic spectroscopy

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Szabó, A., Mohácsi, A., Novák, P., Aladzic, D., Turzó, K., Rakonczay, Z., ... Szabó, G. (2012). Diode laser based photoacoustic gas measuring instruments intended for medical research. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8427). [84272J] https://doi.org/10.1117/12.921644

Diode laser based photoacoustic gas measuring instruments intended for medical research. / Szabó, Anna; Mohácsi, A.; Novák, Péter; Aladzic, Daniela; Turzó, Kinga; Rakonczay, Zoltán; Erös, Gábor; Borós, M.; Nagy, K.; Szabó, Gábor.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8427 2012. 84272J.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Szabó, A, Mohácsi, A, Novák, P, Aladzic, D, Turzó, K, Rakonczay, Z, Erös, G, Borós, M, Nagy, K & Szabó, G 2012, Diode laser based photoacoustic gas measuring instruments intended for medical research. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8427, 84272J, Biophotonics: Photonic Solutions for Better Health Care III, Brussels, Belgium, 4/16/12. https://doi.org/10.1117/12.921644
Szabó A, Mohácsi A, Novák P, Aladzic D, Turzó K, Rakonczay Z et al. Diode laser based photoacoustic gas measuring instruments intended for medical research. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8427. 2012. 84272J https://doi.org/10.1117/12.921644
Szabó, Anna ; Mohácsi, A. ; Novák, Péter ; Aladzic, Daniela ; Turzó, Kinga ; Rakonczay, Zoltán ; Erös, Gábor ; Borós, M. ; Nagy, K. ; Szabó, Gábor. / Diode laser based photoacoustic gas measuring instruments intended for medical research. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8427 2012.
@inproceedings{02979b76a27a4afc990c169cbcf964a8,
title = "Diode laser based photoacoustic gas measuring instruments intended for medical research",
abstract = "Analysis of breath and gases emanated from skin can be used for early and non-invasive diagnosis of various kinds of diseases. Two portable, compact, photoacoustic spectroscopy based trace gas sensors were developed for the detection of methane emanated from skin and ammonia emanated from oral cavity. The light sources were distributed feedback diode lasers emitting at the absorption lines of ammonia and methane, at 1.53 μm and 1.65 μm, respectively. Photoacoustic method ensures high selectivity, therefore cross-sensitivity was negligible even with large amount of water vapor and carbon dioxide in the gas sample. In case of ammonia a preconcentration unit was used to achieve lower minimum detectable concentration. Gas sample from the oral cavity was drawn through a glass tube to the preconcentration unit that chemically bonded ammonia and released it when heated. The minimum detectable concentration of ammonia was 10 ppb for gas sample volume of 250 cm 3. For methane minimum detectable concentration of 0.25 ppm was found with 12 s integration time, and it was proved to be adequate for the detection of methane emanated from human skin and from mice. Instruments measuring methane and ammonia are currently installed at two medical research laboratories at University of Szeged and tested as instruments for non-invasive clinical trials. The aim of the measurements is to determine correlations between diseases or metabolic processes and emanated gases.",
keywords = "Ammonia, Medical research, Methane, Near infrared, Non-invasive, Oral cavity, Photoacoustic spectroscopy",
author = "Anna Szab{\'o} and A. Moh{\'a}csi and P{\'e}ter Nov{\'a}k and Daniela Aladzic and Kinga Turz{\'o} and Zolt{\'a}n Rakonczay and G{\'a}bor Er{\"o}s and M. Bor{\'o}s and K. Nagy and G{\'a}bor Szab{\'o}",
year = "2012",
doi = "10.1117/12.921644",
language = "English",
isbn = "9780819491190",
volume = "8427",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Diode laser based photoacoustic gas measuring instruments intended for medical research

AU - Szabó, Anna

AU - Mohácsi, A.

AU - Novák, Péter

AU - Aladzic, Daniela

AU - Turzó, Kinga

AU - Rakonczay, Zoltán

AU - Erös, Gábor

AU - Borós, M.

AU - Nagy, K.

AU - Szabó, Gábor

PY - 2012

Y1 - 2012

N2 - Analysis of breath and gases emanated from skin can be used for early and non-invasive diagnosis of various kinds of diseases. Two portable, compact, photoacoustic spectroscopy based trace gas sensors were developed for the detection of methane emanated from skin and ammonia emanated from oral cavity. The light sources were distributed feedback diode lasers emitting at the absorption lines of ammonia and methane, at 1.53 μm and 1.65 μm, respectively. Photoacoustic method ensures high selectivity, therefore cross-sensitivity was negligible even with large amount of water vapor and carbon dioxide in the gas sample. In case of ammonia a preconcentration unit was used to achieve lower minimum detectable concentration. Gas sample from the oral cavity was drawn through a glass tube to the preconcentration unit that chemically bonded ammonia and released it when heated. The minimum detectable concentration of ammonia was 10 ppb for gas sample volume of 250 cm 3. For methane minimum detectable concentration of 0.25 ppm was found with 12 s integration time, and it was proved to be adequate for the detection of methane emanated from human skin and from mice. Instruments measuring methane and ammonia are currently installed at two medical research laboratories at University of Szeged and tested as instruments for non-invasive clinical trials. The aim of the measurements is to determine correlations between diseases or metabolic processes and emanated gases.

AB - Analysis of breath and gases emanated from skin can be used for early and non-invasive diagnosis of various kinds of diseases. Two portable, compact, photoacoustic spectroscopy based trace gas sensors were developed for the detection of methane emanated from skin and ammonia emanated from oral cavity. The light sources were distributed feedback diode lasers emitting at the absorption lines of ammonia and methane, at 1.53 μm and 1.65 μm, respectively. Photoacoustic method ensures high selectivity, therefore cross-sensitivity was negligible even with large amount of water vapor and carbon dioxide in the gas sample. In case of ammonia a preconcentration unit was used to achieve lower minimum detectable concentration. Gas sample from the oral cavity was drawn through a glass tube to the preconcentration unit that chemically bonded ammonia and released it when heated. The minimum detectable concentration of ammonia was 10 ppb for gas sample volume of 250 cm 3. For methane minimum detectable concentration of 0.25 ppm was found with 12 s integration time, and it was proved to be adequate for the detection of methane emanated from human skin and from mice. Instruments measuring methane and ammonia are currently installed at two medical research laboratories at University of Szeged and tested as instruments for non-invasive clinical trials. The aim of the measurements is to determine correlations between diseases or metabolic processes and emanated gases.

KW - Ammonia

KW - Medical research

KW - Methane

KW - Near infrared

KW - Non-invasive

KW - Oral cavity

KW - Photoacoustic spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=84861935644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861935644&partnerID=8YFLogxK

U2 - 10.1117/12.921644

DO - 10.1117/12.921644

M3 - Conference contribution

SN - 9780819491190

VL - 8427

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -