Diode laser based photoacoustic gas measuring instruments intended for medical research

Anna Szabó, Árpád Mohácsi, Péter Novák, Daniela Aladzic, Kinga Turzó, Zoltán Rakonczay, Gábor Erös, Mihály Boros, Katalin Nagy, Gábor Szabó

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Analysis of breath and gases emanated from skin can be used for early and non-invasive diagnosis of various kinds of diseases. Two portable, compact, photoacoustic spectroscopy based trace gas sensors were developed for the detection of methane emanated from skin and ammonia emanated from oral cavity. The light sources were distributed feedback diode lasers emitting at the absorption lines of ammonia and methane, at 1.53 μm and 1.65 μm, respectively. Photoacoustic method ensures high selectivity, therefore cross-sensitivity was negligible even with large amount of water vapor and carbon dioxide in the gas sample. In case of ammonia a preconcentration unit was used to achieve lower minimum detectable concentration. Gas sample from the oral cavity was drawn through a glass tube to the preconcentration unit that chemically bonded ammonia and released it when heated. The minimum detectable concentration of ammonia was 10 ppb for gas sample volume of 250 cm 3. For methane minimum detectable concentration of 0.25 ppm was found with 12 s integration time, and it was proved to be adequate for the detection of methane emanated from human skin and from mice. Instruments measuring methane and ammonia are currently installed at two medical research laboratories at University of Szeged and tested as instruments for non-invasive clinical trials. The aim of the measurements is to determine correlations between diseases or metabolic processes and emanated gases.

Original languageEnglish
Title of host publicationBiophotonics
Subtitle of host publicationPhotonic Solutions for Better Health Care III
DOIs
Publication statusPublished - Jun 12 2012
EventBiophotonics: Photonic Solutions for Better Health Care III - Brussels, Belgium
Duration: Apr 16 2012Apr 19 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8427
ISSN (Print)1605-7422

Other

OtherBiophotonics: Photonic Solutions for Better Health Care III
CountryBelgium
CityBrussels
Period4/16/124/19/12

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Keywords

  • Ammonia
  • Medical research
  • Methane
  • Near infrared
  • Non-invasive
  • Oral cavity
  • Photoacoustic spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Szabó, A., Mohácsi, Á., Novák, P., Aladzic, D., Turzó, K., Rakonczay, Z., Erös, G., Boros, M., Nagy, K., & Szabó, G. (2012). Diode laser based photoacoustic gas measuring instruments intended for medical research. In Biophotonics: Photonic Solutions for Better Health Care III [84272J] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8427). https://doi.org/10.1117/12.921644