Diminished coronary flow velocity reserve and aortic distensibility in elderly patients with chest pain and negative coronary angiograms

Attila Nemes, T. Forster, M. Csanády

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6 Citations (Scopus)

Abstract

Background and aims: Aging is a dominant process that alters vascular stiffness, endothelial function and coronary flow regulation. The objective of our work was to assess simultaneously the elastic properties of the descending aorta and coronary flow velocity reserve (CFR) during the same transesophageal echocardiography (TEE) in elderly patients. Methods: The following patients with normal epicardial coronary arteries were compared: 30 subjects under 55 years of age (group 1) and 17 patients over 55 years (group 2). A complete TEE examination was carried out in all patients, and the following aortic elastic properties were calculated from aortic diameter and blood pressure data: aortic elastic modulus [E(p)] and Young's circumferential static elastic modulus [E(s)]. Doppler evaluation of left anterior descending coronary flow velocity was performed in resting conditions and after administration of 0.56 mg/Kg dipyridamole over.4 min. Peak coronary flow velocities were measured at the 6th minute at maximum vasodilation. CFR was estimated as the ratio of hyperemic to basal peak diastolic coronary flow velocities. Results: Peak hyperemic diastolic coronary flow velocities were significantly decreased (139.1±35.6 cm/s vs 105.7±39.7 cm/ s, p55 years. CFR was decreased (2.67±1.05 vs 2.13±0.56, p3 mmHg, 0.59±0.49 vs 0.94±0.65, p3 mmHg, 5.70±4.30 vs 8.47±5.14, p55 years. A correlation was found between CFR and E(p) (r=-0.20, p

Original languageEnglish
Pages (from-to)297-301
Number of pages5
JournalAging clinical and experimental research
Volume20
Issue number4
Publication statusPublished - Aug 2008

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Chest Pain
Angiography
Elastic Modulus
Transesophageal Echocardiography
Vascular Stiffness
Dipyridamole
Thoracic Aorta
Vasodilation
Coronary Vessels
Arterial Pressure
Age Groups

Keywords

  • Aortic distensibility
  • Coronary flow reserve
  • Distensibility
  • Echocardiography
  • Stiffness

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

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title = "Diminished coronary flow velocity reserve and aortic distensibility in elderly patients with chest pain and negative coronary angiograms",
abstract = "Background and aims: Aging is a dominant process that alters vascular stiffness, endothelial function and coronary flow regulation. The objective of our work was to assess simultaneously the elastic properties of the descending aorta and coronary flow velocity reserve (CFR) during the same transesophageal echocardiography (TEE) in elderly patients. Methods: The following patients with normal epicardial coronary arteries were compared: 30 subjects under 55 years of age (group 1) and 17 patients over 55 years (group 2). A complete TEE examination was carried out in all patients, and the following aortic elastic properties were calculated from aortic diameter and blood pressure data: aortic elastic modulus [E(p)] and Young's circumferential static elastic modulus [E(s)]. Doppler evaluation of left anterior descending coronary flow velocity was performed in resting conditions and after administration of 0.56 mg/Kg dipyridamole over.4 min. Peak coronary flow velocities were measured at the 6th minute at maximum vasodilation. CFR was estimated as the ratio of hyperemic to basal peak diastolic coronary flow velocities. Results: Peak hyperemic diastolic coronary flow velocities were significantly decreased (139.1±35.6 cm/s vs 105.7±39.7 cm/ s, p55 years. CFR was decreased (2.67±1.05 vs 2.13±0.56, p3 mmHg, 0.59±0.49 vs 0.94±0.65, p3 mmHg, 5.70±4.30 vs 8.47±5.14, p55 years. A correlation was found between CFR and E(p) (r=-0.20, p",
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T1 - Diminished coronary flow velocity reserve and aortic distensibility in elderly patients with chest pain and negative coronary angiograms

AU - Nemes, Attila

AU - Forster, T.

AU - Csanády, M.

PY - 2008/8

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N2 - Background and aims: Aging is a dominant process that alters vascular stiffness, endothelial function and coronary flow regulation. The objective of our work was to assess simultaneously the elastic properties of the descending aorta and coronary flow velocity reserve (CFR) during the same transesophageal echocardiography (TEE) in elderly patients. Methods: The following patients with normal epicardial coronary arteries were compared: 30 subjects under 55 years of age (group 1) and 17 patients over 55 years (group 2). A complete TEE examination was carried out in all patients, and the following aortic elastic properties were calculated from aortic diameter and blood pressure data: aortic elastic modulus [E(p)] and Young's circumferential static elastic modulus [E(s)]. Doppler evaluation of left anterior descending coronary flow velocity was performed in resting conditions and after administration of 0.56 mg/Kg dipyridamole over.4 min. Peak coronary flow velocities were measured at the 6th minute at maximum vasodilation. CFR was estimated as the ratio of hyperemic to basal peak diastolic coronary flow velocities. Results: Peak hyperemic diastolic coronary flow velocities were significantly decreased (139.1±35.6 cm/s vs 105.7±39.7 cm/ s, p55 years. CFR was decreased (2.67±1.05 vs 2.13±0.56, p3 mmHg, 0.59±0.49 vs 0.94±0.65, p3 mmHg, 5.70±4.30 vs 8.47±5.14, p55 years. A correlation was found between CFR and E(p) (r=-0.20, p

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