Dimethoate-induced toxic cardiac failure in the guinea pig

György Marosi, János Iván, László Nagymajtényi, Imre Csatlós, Anna Tószegi

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In anaesthetized guinea-pigs treated with lethal doses of dimethoate, cardiac failure and serious ECG disturbances developed in the early phase of intoxication. The toxic cardiac phenomena appeared to be unrelated to the degree of cholinesterase inhibition, but showed a close correlation with myocardial dimethoate concentration. Cardiac failure and mortality were first observed at a critical pesticide level of about 110 μg/g, while a level of 221 μg/g resulted in death in all cases. The present investigation refers to the direct effect of the pesticide on the myocardium, independent of its anticholinesterase action.

Original languageEnglish
Pages (from-to)142-143
Number of pages2
JournalArchives of Toxicology
Issue number2
Publication statusPublished - Jun 1 1985



  • Cholinesterase activity
  • Dimethoate intoxication
  • ECG disturbances
  • Guinea-pig
  • Pesticide level

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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