(-)-Dihydro-apovincaminic acid ethyl ester, preparation and use as a chiral modifier in enantioselective heterogeneous catalytic hydrogenations

A. Tungler, T. Máthé, T. Tarnai, K. Fodor, G. Tóth, J. Kajtár, I. Kolossváry, B. Herényi, R. A. Sheldon

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The preparation, characterisation and use of (-)-dihydro-apovincaminic acid ethyl ester as a chiral modifier in heterogeneous catalytic asymmetric hydrogenations is reported. The epimeric compositions were determined using NMR and HPLC methods and circular dichroism spectroscopy was used to detect the interaction between the chiral modifier and the substrate.

Original languageEnglish
Pages (from-to)2395-2402
Number of pages8
JournalTetrahedron Asymmetry
Volume6
Issue number9
DOIs
Publication statusPublished - 1995

Fingerprint

Circular dichroism spectroscopy
Hydrogenation
Circular Dichroism
dichroism
hydrogenation
esters
Spectrum Analysis
Esters
High Pressure Liquid Chromatography
Nuclear magnetic resonance
preparation
nuclear magnetic resonance
acids
Acids
Substrates
Chemical analysis
spectroscopy
interactions
apovincaminic acid

ASJC Scopus subject areas

  • Catalysis
  • Inorganic Chemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

(-)-Dihydro-apovincaminic acid ethyl ester, preparation and use as a chiral modifier in enantioselective heterogeneous catalytic hydrogenations. / Tungler, A.; Máthé, T.; Tarnai, T.; Fodor, K.; Tóth, G.; Kajtár, J.; Kolossváry, I.; Herényi, B.; Sheldon, R. A.

In: Tetrahedron Asymmetry, Vol. 6, No. 9, 1995, p. 2395-2402.

Research output: Contribution to journalArticle

Tungler, A. ; Máthé, T. ; Tarnai, T. ; Fodor, K. ; Tóth, G. ; Kajtár, J. ; Kolossváry, I. ; Herényi, B. ; Sheldon, R. A. / (-)-Dihydro-apovincaminic acid ethyl ester, preparation and use as a chiral modifier in enantioselective heterogeneous catalytic hydrogenations. In: Tetrahedron Asymmetry. 1995 ; Vol. 6, No. 9. pp. 2395-2402.
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AU - Tungler, A.

AU - Máthé, T.

AU - Tarnai, T.

AU - Fodor, K.

AU - Tóth, G.

AU - Kajtár, J.

AU - Kolossváry, I.

AU - Herényi, B.

AU - Sheldon, R. A.

PY - 1995

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