Diffusion MRI measured white matter microstructure as a biomarker of neurodegeneration in preclinical Huntington's disease

Zsigmond Tomás Kincses, Nikoletta Szabó, Eszter Tóth, Dénes Zádori, Péter Faragó, Dezso Németh, Karolina Janacsek, Magor Babos, P. Klivényi, L. Vécsei

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background - Huntington's disease is a progressive neurodegenerative disease, genetically determined by CAG trinucleotide expansions in the IT15 gene. The onset of the symptoms is related to the number of CAG triplets. Because the patients are asymptomatic in the early phase of the disease, in vivo biomarkers are needed to follow up the neurodegeneration and to test putative neuroprotective approaches. One such promising biomarker is the diffusion MRI measured microstructural alteration of the white matter. Methods - Seven presymtomatic, mutation carriers and ten age-matched healthy controls were included in the study. Diffusion parameters were compared between groups and correlated with measures describing neurodegeneration. In order to reduce the possible misregistration bias due to atrophy the analysis was restricted to the core of each fibre bundles as defined by maximal fractional anisotropy (TractBased Spatial Statistics). Results - Decreased fractional anisotropy, along with increased mean, parallel and perpendicular diffusivity was found in white matter tracts, mainly in the corpus callosum. An inverse correlation was detected between the fractional anisotropy and neurodegeneration score (derived from the number of CAG triplets and the patient age) from the areas of the left precentral gyrus, frontal lobe, corpus callosum and the capsula extrema. Altered diffusion parameters are promising biomarkers of the neurodegeneration in Huntington's disease.

Original languageEnglish
Pages (from-to)399-405
Number of pages7
JournalIdeggyógyászati szemle
Volume66
Issue number11-12
Publication statusPublished - 2013

Fingerprint

Diffusion Magnetic Resonance Imaging
Huntington Disease
Anisotropy
Corpus Callosum
Biomarkers
Frontal Lobe
Neurodegenerative Diseases
Atrophy
Mutation
Genes
White Matter

Keywords

  • Biomarkers of neurodegeneration
  • Diffusion paramteres
  • Huntington's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Kincses, Z. T., Szabó, N., Tóth, E., Zádori, D., Faragó, P., Németh, D., ... Vécsei, L. (2013). Diffusion MRI measured white matter microstructure as a biomarker of neurodegeneration in preclinical Huntington's disease. Ideggyógyászati szemle, 66(11-12), 399-405.

Diffusion MRI measured white matter microstructure as a biomarker of neurodegeneration in preclinical Huntington's disease. / Kincses, Zsigmond Tomás; Szabó, Nikoletta; Tóth, Eszter; Zádori, Dénes; Faragó, Péter; Németh, Dezso; Janacsek, Karolina; Babos, Magor; Klivényi, P.; Vécsei, L.

In: Ideggyógyászati szemle, Vol. 66, No. 11-12, 2013, p. 399-405.

Research output: Contribution to journalArticle

Kincses, ZT, Szabó, N, Tóth, E, Zádori, D, Faragó, P, Németh, D, Janacsek, K, Babos, M, Klivényi, P & Vécsei, L 2013, 'Diffusion MRI measured white matter microstructure as a biomarker of neurodegeneration in preclinical Huntington's disease', Ideggyógyászati szemle, vol. 66, no. 11-12, pp. 399-405.
Kincses, Zsigmond Tomás ; Szabó, Nikoletta ; Tóth, Eszter ; Zádori, Dénes ; Faragó, Péter ; Németh, Dezso ; Janacsek, Karolina ; Babos, Magor ; Klivényi, P. ; Vécsei, L. / Diffusion MRI measured white matter microstructure as a biomarker of neurodegeneration in preclinical Huntington's disease. In: Ideggyógyászati szemle. 2013 ; Vol. 66, No. 11-12. pp. 399-405.
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