Diffuse plasmacytosis in a child with brainstem glioma following multiagent chemotherapy and intensive growth factor support

Csilla Csáki, Thomas Ferencz, György Sipos, László Kopper, Dezsö Schuler, Joseph D. Borsi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The use of granulocyte colony-stimulating factor (G-CSF) or granulocyte- macrophage-colony-stimulating factor (GM-CSF) in order to abrogate chemotherapy-induced neutropenia has become a routine part of many cancer treatment regimens. However, there are still very few data available about possible complications related to repeated or prolonged use of these agents in patients with malignant solid tumors. The authors report a child with brainstem glioma who received repeated cycles of multiagent chemotherapy with G- or GM-CSF support. During this period of 10 months, no clinical side effects were observed that could have been attributed to growth factor administration. However, postmortem histological examination revealed the presence of diffuse plasmacytosis, a rare hematological disorder in childhood. Undifferentiated plasma cells of nonmonoclonal origin could be demonstrated infiltrating bone marrow, lungs, and lymph nodes of the patient. Based on previously published in vitro and in vivo evidence on the interleukin-6 (IL-6)-mediated stimulatory effect of G- and GM-CSF on myeloma cell proliferation, the authors suggest a possible link between extensive growth factor support and the development of plasmacytosis in this patient.

Original languageEnglish
Pages (from-to)367-371
Number of pages5
JournalMedical and pediatric oncology
Volume26
Issue number5
DOIs
Publication statusPublished - May 1 1996

Keywords

  • G-CSF
  • GM-CSF
  • chemotherapy
  • glioma
  • growth factor
  • plasmacytosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Diffuse plasmacytosis in a child with brainstem glioma following multiagent chemotherapy and intensive growth factor support'. Together they form a unique fingerprint.

  • Cite this