Differentiation of human embryonal carcinoma cells induces human immunodeficiency virus permissiveness which is stimulated by human cytomegalovirus coinfection

G. Hirka, K. Prakash, H. Kawashima, S. A. Plotkin, P. W. Andrews, E. Gonczol

Research output: Contribution to journalComment/debate

26 Citations (Scopus)


Human immunodeficiency virus (HIV) replicates in differentiated but not undifferentiated NTERA-2 human embryonal carcinoma cells; neither cell type expresses CD4. Susceptibility of the differentiated cells is enhanced by coinfection with cytomegalovirus. HIV infection induces lactoseries glycolipids, suggesting a mechanism whereby HIV might interfere with normal embryogenesis.

Original languageEnglish
Pages (from-to)2732-2735
Number of pages4
JournalJournal of Virology
Issue number5
Publication statusPublished - Jan 1 1991


ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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