Differentiation markers in hemangiopericytoma

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Abstract

Normal pericytes were found to express factor XIIIa (F-XIII) and histocompatibility antigen HLA-DR. These markers were studied in 15 hemangiopericytomas (HPC) and 16 other tumors with an HPC-like pattern. A subpopulation of tumor cells expressing F-XIII and HLA-DR antigens was a constant feature of HPC and supported their pericytic origin. Meningeal HPC did not differ in phenotype from peripheral soft tissue HPC. Most tumors with an HPC-like pattern (including synovial sarcomas, malignant schwannomas, leiomyosarcomas, and liposarcomas) were negative for F-XIII and HLA-DR. Malignant fibrous histiocytomas, however, invariably contained a subpopulation expressing these antigens. Therefore, F-XIII can be considered as a marker of fibrohistiocytic differentiation in HPC. Individual tumor cells in HPC occasionally were positive for factor VIII-related antigen (F- VIII-R-Ag), suggesting that the spectrum of differentiation in HPC may include the endothelial cell line. The differentiation characteristics of HPC support the concept that pericytes are primitive cells that may act as precursors to other mesenchymal cells.

Original languageEnglish
Pages (from-to)133-140
Number of pages8
JournalCancer
Volume69
Issue number1
Publication statusPublished - 1992

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Hemangiopericytoma
Differentiation Antigens
Factor XIIIa
HLA-DR Antigens
Pericytes
Neoplasms
Synovial Sarcoma
Malignant Fibrous Histiocytoma
Liposarcoma
Histocompatibility Antigens
Leiomyosarcoma
Neurilemmoma
von Willebrand Factor
Endothelial Cells
Phenotype

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Differentiation markers in hemangiopericytoma. / Nemes, Z.

In: Cancer, Vol. 69, No. 1, 1992, p. 133-140.

Research output: Contribution to journalArticle

Nemes, Z 1992, 'Differentiation markers in hemangiopericytoma', Cancer, vol. 69, no. 1, pp. 133-140.
Nemes, Z. / Differentiation markers in hemangiopericytoma. In: Cancer. 1992 ; Vol. 69, No. 1. pp. 133-140.
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