Differentiated thyroid cancer and outcome in iodine deficiency

F. Gyory, Gy Balazs, E. Nagy, F. Juhasz, E. Mezősi, S. Szakáll, J. Math, G. Lukacs

Research output: Contribution to journalArticle

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Abstract

Aims. Factors influencing prognosis and long-term outcome of thyroid cancer have been described by several groups. We wished to asses the previously described prognostic factors in a moderately iodine deficient region in Hungary. Methods. Four hundred and fifty-four out of 492 patients who had surgery for papillary thyroid cancer (PTC, 386 cases) and follicular thyroid cancer (FTC, 106 cases) between 1971 and 1998 were analyzed. Survival curves were compared using the Kaplan-Meier method and Cox regression analysis. Results. The 10 and 20-year survival rates were 87.9 and 84% for PTC, and 78.2 and 78.2% for FTC. In PTC, extrathyroidal invasion (p <0.0001), lymph node metastasis (p <0.0001), distant metastasis (p <0.0001), and age over 40 years (p = 0.002) were significant adverse predictors. In FTC, extrathyroidal invasion (p = 0.003), distant metastases (p <0.0001), and age over 40 years (p = 0.011) were significant adverse predictors. Conclusion. Iodine intake did not appear to influence survival. The incidence of follicular cancer, which has less favourable prognosis, was higher in iodine deficient regions. This supports the importance of iodine supplementation in these areas.

Original languageEnglish
Pages (from-to)325-331
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume30
Issue number3
DOIs
Publication statusPublished - Apr 2004

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Thyroid Neoplasms
Iodine
Factor IX
Neoplasm Metastasis
Survival
Hungary
Equidae
Survival Rate
Lymph Nodes
Regression Analysis
Incidence
Neoplasms

Keywords

  • Follicular cancer
  • Papillary cancer
  • Prognostic risk factors

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Differentiated thyroid cancer and outcome in iodine deficiency. / Gyory, F.; Balazs, Gy; Nagy, E.; Juhasz, F.; Mezősi, E.; Szakáll, S.; Math, J.; Lukacs, G.

In: European Journal of Surgical Oncology, Vol. 30, No. 3, 04.2004, p. 325-331.

Research output: Contribution to journalArticle

Gyory, F. ; Balazs, Gy ; Nagy, E. ; Juhasz, F. ; Mezősi, E. ; Szakáll, S. ; Math, J. ; Lukacs, G. / Differentiated thyroid cancer and outcome in iodine deficiency. In: European Journal of Surgical Oncology. 2004 ; Vol. 30, No. 3. pp. 325-331.
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