Differentially expressed micrornas in small cell lung cancer

Edit Miko, Zsolt Czimmerer, Eszter Cśanky, Gábor Boros, Júlia Buslig, B. Dezső, B. Scholtz

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Expression of microRNAs (miRNAs) is characteristically altered in cancer, and they may play a role in cancer development and progression. The authors performed microarray and real-time quantitative reverse transcriptasepolymerase chain reaction (RT-PCR) analyses to determine the miRNA expression profile of primary small cell lung cancer. Here we show that at least 24 miRNAs are differentially expressed between normal lung and primary small cell lung cancer (SCLC) tumors. These include miR-301, miR-183/96/182, miR-126, and miR-223, which are microRNAs deregulated in other tumor types as well; and other miRNAs, such as miR-374 and miR-210, not previously reported in association with lung cancer. The aberrant miRNA profile of SCLC may offer new insights in the biology of this aggressive tumor, and could potentially provide novel diagnostic markers.

Original languageEnglish
Pages (from-to)646-664
Number of pages19
JournalExperimental Lung Research
Volume35
Issue number8
DOIs
Publication statusPublished - Oct 14 2009

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Small Cell Lung Carcinoma
MicroRNAs
Cells
Tumors
Neoplasms
Microarrays
Lung Neoplasms
Association reactions
Lung

Keywords

  • MicroRNA
  • Small cell lung cancer

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

Differentially expressed micrornas in small cell lung cancer. / Miko, Edit; Czimmerer, Zsolt; Cśanky, Eszter; Boros, Gábor; Buslig, Júlia; Dezső, B.; Scholtz, B.

In: Experimental Lung Research, Vol. 35, No. 8, 14.10.2009, p. 646-664.

Research output: Contribution to journalArticle

Miko, Edit ; Czimmerer, Zsolt ; Cśanky, Eszter ; Boros, Gábor ; Buslig, Júlia ; Dezső, B. ; Scholtz, B. / Differentially expressed micrornas in small cell lung cancer. In: Experimental Lung Research. 2009 ; Vol. 35, No. 8. pp. 646-664.
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