Differential Sensitivity of the Species of Candida parapsilosis Sensu Lato Complex Against Statins

Judit Szenzenstein, A. Gácser, Zsuzsanna Grózer, Zoltán Farkas, K. Nagy, C. Vágvölgyi, János Márki-Zay, I. Pfeiffer

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis are human fungal pathogens with clinical importance. The recently reclassified three closely related species have significant variation in virulence, clinical prevalence and susceptibility characteristics to different antifungal compounds. The aim of this study was to investigate the in vitro activity of atorvastatin and fluvastatin against C. metapsilosis, C. orthopsilosis and C. parapsilosis. Susceptibility tests showed that C. parapsilosis was the most sensitive while C. orthopsilosis was the least susceptible species to both drugs. On the basis of the differential sensitivity, we developed a simple, reliable and highly cost-effective plate assay to distinguish these closely related species. Applying this method, 54 isolates belonging to the C. parapsilosis sensu lato complex deposited in Szeged Microbial Collection could be sorted into the three species with 100 % probability.

Original languageEnglish
Pages (from-to)211-217
Number of pages7
JournalMycopathologia
Volume176
Issue number3-4
DOIs
Publication statusPublished - 2013

Fingerprint

Candida parapsilosis
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Candida
fluvastatin
Virulence
Costs and Cost Analysis
virulence
drugs
Pharmaceutical Preparations
pathogens
assays
testing

Keywords

  • Atorvastatin
  • C. orthopsilosis
  • C. parapsilosis
  • Candida metapsilosis
  • Fluvastatin

ASJC Scopus subject areas

  • Plant Science
  • Agronomy and Crop Science
  • Applied Microbiology and Biotechnology
  • Microbiology
  • veterinary (miscalleneous)

Cite this

Differential Sensitivity of the Species of Candida parapsilosis Sensu Lato Complex Against Statins. / Szenzenstein, Judit; Gácser, A.; Grózer, Zsuzsanna; Farkas, Zoltán; Nagy, K.; Vágvölgyi, C.; Márki-Zay, János; Pfeiffer, I.

In: Mycopathologia, Vol. 176, No. 3-4, 2013, p. 211-217.

Research output: Contribution to journalArticle

Szenzenstein, Judit ; Gácser, A. ; Grózer, Zsuzsanna ; Farkas, Zoltán ; Nagy, K. ; Vágvölgyi, C. ; Márki-Zay, János ; Pfeiffer, I. / Differential Sensitivity of the Species of Candida parapsilosis Sensu Lato Complex Against Statins. In: Mycopathologia. 2013 ; Vol. 176, No. 3-4. pp. 211-217.
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