Differential scanning calorimetry to study the possible ternary complex formation between chlorhexidine, phosphatidylcholine and some nonionic tenzides

Maria Szögyi, T. Cserháti, László Lelkes

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of chlorhexidine and its molecular complexes with some nonionic tenzides (Tween and Myrj series) on the phase transfer parameters of dipalmitoylphosphatidylcholine has been studied by differential scanning calorimetry. The application of principal component analysis facilitated the evaluation of the experimental data matrix. It was found that both the lipophilicity of the tenzide and the strength of interaction between chlorhexidine and nonionic tenzide had a considerable impact on some of the phase transition parameters of dipalmitoylphosphatidylcholine. These findings indicate the possible existence of ternary complexes. This ternary complex formation may cause a decrease of chlorhexidine activity in the presence of nonionic tenzides.

Original languageEnglish
Pages (from-to)31-43
Number of pages13
JournalJournal of Biochemical and Biophysical Methods
Volume23
Issue number1
DOIs
Publication statusPublished - 1991

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Chlorhexidine
Differential Scanning Calorimetry
Phosphatidylcholines
1,2-Dipalmitoylphosphatidylcholine
Differential scanning calorimetry
Polysorbates
Phase Transition
Principal Component Analysis
Principal component analysis
Phase transitions

Keywords

  • Chlorhexidine-phosphatidylcholine-nonionic tenzide complex
  • Differential scanning calorimety
  • Principal component analysis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Cite this

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abstract = "The effect of chlorhexidine and its molecular complexes with some nonionic tenzides (Tween and Myrj series) on the phase transfer parameters of dipalmitoylphosphatidylcholine has been studied by differential scanning calorimetry. The application of principal component analysis facilitated the evaluation of the experimental data matrix. It was found that both the lipophilicity of the tenzide and the strength of interaction between chlorhexidine and nonionic tenzide had a considerable impact on some of the phase transition parameters of dipalmitoylphosphatidylcholine. These findings indicate the possible existence of ternary complexes. This ternary complex formation may cause a decrease of chlorhexidine activity in the presence of nonionic tenzides.",
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author = "Maria Sz{\"o}gyi and T. Cserh{\'a}ti and L{\'a}szl{\'o} Lelkes",
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T1 - Differential scanning calorimetry to study the possible ternary complex formation between chlorhexidine, phosphatidylcholine and some nonionic tenzides

AU - Szögyi, Maria

AU - Cserháti, T.

AU - Lelkes, László

PY - 1991

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N2 - The effect of chlorhexidine and its molecular complexes with some nonionic tenzides (Tween and Myrj series) on the phase transfer parameters of dipalmitoylphosphatidylcholine has been studied by differential scanning calorimetry. The application of principal component analysis facilitated the evaluation of the experimental data matrix. It was found that both the lipophilicity of the tenzide and the strength of interaction between chlorhexidine and nonionic tenzide had a considerable impact on some of the phase transition parameters of dipalmitoylphosphatidylcholine. These findings indicate the possible existence of ternary complexes. This ternary complex formation may cause a decrease of chlorhexidine activity in the presence of nonionic tenzides.

AB - The effect of chlorhexidine and its molecular complexes with some nonionic tenzides (Tween and Myrj series) on the phase transfer parameters of dipalmitoylphosphatidylcholine has been studied by differential scanning calorimetry. The application of principal component analysis facilitated the evaluation of the experimental data matrix. It was found that both the lipophilicity of the tenzide and the strength of interaction between chlorhexidine and nonionic tenzide had a considerable impact on some of the phase transition parameters of dipalmitoylphosphatidylcholine. These findings indicate the possible existence of ternary complexes. This ternary complex formation may cause a decrease of chlorhexidine activity in the presence of nonionic tenzides.

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