Emlodaganatos betegek vérplazmájának differenciál pásztázó kalorimetriás vizsgálata.

Translated title of the contribution: [Differential scanning calorimetry of blood plasma in breast cancer patients].

István Zapf, Tamás Fekecs, Medhi Moezzi, György Tizedes, Gábor Pavlovics, Endre Kálmán, Péter Ors Horváth, Andrea Ferencz

Research output: Contribution to journalArticle

Abstract

Breast cancer is the commonest cause of cancer death in women worldwide. Its incidence has been increasing for many years in economically developed countries. Differential scanning calorimetry (DSC) is a thermoanalytical technique which monitors small heat changes between sample and reference materials. This examination is a validly efficient method for the demonstration of structural changes not only in the physical sciences, but in numerous human oncological diseases. The goal of this study was to measure DSC thermogram of blood plasma in breast cancer patients with different stages. Nineteen women with different tumor diameter (0.5-7.5 mm) and with or without regional lymph node metastases were involved in the study. Preoperatively peripheral blood samples were collected from the patients and from healthy controls, and plasma components were analysed by SETARAM micro DSC-II calorimeter. The diameter of the tumor tissue and the number of metastatic lymph nodes were evaluated on the basis of postoperative histological results. In the current study we found difference in changes of the thermal parameters (transition temperature, calorimetric enthalpy) of breast cancer patients' plasma components. Moreover, a tendency has been found for association of these results with tumor size and with the degree of regional lymph node involvement. Preliminary study of the clinical utility of DSC technology arises, even though there is no data in the literature. In cases of breast cancer the blood plasma may be suitable for DSC analysis for diagnosis or staging as well. In order to clarify the relationships we are planning further studies.

Original languageHungarian
Pages (from-to)274-279
Number of pages6
JournalMagyar Onkologia
Volume56
Issue number4
Publication statusPublished - Dec 2012
Externally publishedYes

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Differential Scanning Calorimetry
Breast Neoplasms
Lymph Nodes
Neoplasms
Hot Temperature
Natural Science Disciplines
Transition Temperature
Developed Countries
Cause of Death
Neoplasm Metastasis
Technology
Incidence

ASJC Scopus subject areas

  • Oncology

Cite this

Emlodaganatos betegek vérplazmájának differenciál pásztázó kalorimetriás vizsgálata. / Zapf, István; Fekecs, Tamás; Moezzi, Medhi; Tizedes, György; Pavlovics, Gábor; Kálmán, Endre; Horváth, Péter Ors; Ferencz, Andrea.

In: Magyar Onkologia, Vol. 56, No. 4, 12.2012, p. 274-279.

Research output: Contribution to journalArticle

Zapf I, Fekecs T, Moezzi M, Tizedes G, Pavlovics G, Kálmán E et al. Emlodaganatos betegek vérplazmájának differenciál pásztázó kalorimetriás vizsgálata. Magyar Onkologia. 2012 Dec;56(4):274-279.
Zapf, István ; Fekecs, Tamás ; Moezzi, Medhi ; Tizedes, György ; Pavlovics, Gábor ; Kálmán, Endre ; Horváth, Péter Ors ; Ferencz, Andrea. / Emlodaganatos betegek vérplazmájának differenciál pásztázó kalorimetriás vizsgálata. In: Magyar Onkologia. 2012 ; Vol. 56, No. 4. pp. 274-279.
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