Differential scanning calorimetric examination of the interfacial membrane in failed hip joint replacements

I. Naumov, D. Lőrinczy, L. Vámhidy, P. Than, N. Wiegand

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Aseptic and septic periprosthetic osteolysis following total hip arthroplasty has become increasingly recognized as a major clinical problem. An aggressive granulomatous tissue, the interfacial membrane, develops at the interface between the bone and the prostheses or the bone and the cement. Our hypothesis was that during the septic and aseptic loosening of the total hip arthroplasty, there is a clear pathological abnormality in the tissue elements building up the interfacial membrane, which is responsible for the different aetiologies of the disease and could be monitored besides the classical methods by differential scanning calorimetry. In our study, the interfacial membrane pieces removed during operations of revision hip arthroplasties in the cases of aseptic loosening and during prosthesis removals in the cases of septic implant loosening. We investigated stem parts of cemented hip arthroplasties only. Our measurements were carried out on eight septic and 12 aseptic samples. With our investigations, we could demonstrate that DSC is a useful and wellapplicable method for the investigation of the interfacial membrane that develops in septic and aseptic loosening of hip arthroplasty. DSC scans clearly demonstrated significant differences between the different types and conditions of samples (aseptic membrane: Tm =62.2°C and DHcal =2.13 J/g, septic membrane: Tm =60.2°C and DHcal =3.22 J/g,). These investigations can help us make a correct diagnosis in the problematic cases of loosened total hip arthroplasty. To decide the possible septic feature of a given sample, calorimetry could serve as one of the quickest procedures available.

Original languageEnglish
Pages (from-to)783-787
Number of pages5
JournalJournal of Thermal Analysis and Calorimetry
Volume109
Issue number2
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Arthroplasty
examination
membranes
Membranes
Scanning
scanning
bones
heat measurement
Tissue
Bone Cements
abnormalities
Calorimetry
cements
Prosthetics
stems
Differential scanning calorimetry
Bone

Keywords

  • DSC
  • Hip arthroplasty
  • Interfacial membrane
  • Periprosthetic osteolysis

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Condensed Matter Physics

Cite this

Differential scanning calorimetric examination of the interfacial membrane in failed hip joint replacements. / Naumov, I.; Lőrinczy, D.; Vámhidy, L.; Than, P.; Wiegand, N.

In: Journal of Thermal Analysis and Calorimetry, Vol. 109, No. 2, 08.2012, p. 783-787.

Research output: Contribution to journalArticle

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