Differential replication of human immunodeficiency virus type 1 in CD8- and CD8+ subsets of natural killer cells: Relationship to cytokine production pattern

F. Tóth, Peter Mosborg-Petersen, Jolán Kiss, George Aboagye-Mathiesen, Milan Zdravkovic, Henrik Hager, Peter Ebbesen

Research output: Contribution to journalArticle

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Abstract

CD8+ and CD8- subsets of peripheral blood natural killer (NK) cells were examined for susceptibility to infection with human immunodeficiency virus type 1 (HIV-1) and for the ability to produce various types of interferon (IFN) and tumor necrosis factor (TNF). HIV-1 was preferentially grown in CD8+ NK cells. The ability of CD8- NK cells to suppress HIV-1 replication was related to their ability to produce alpha IFN (IFN-α) upon viral induction. Induction with interleukin-2 resulted in IFN-γ production in both subsets of NK cells. In the CD8+ subset, IFN-γ and HIV-1 mutually enhanced the production of TNF alpha, leading to hyperactivation of viral replication, whereas in CD8- NK cells IFN-γ primed HIV-induced IFN-α production. The dichotomous effects of IFN-γ on HIV-1 replication were dependent on the IFN-α-producing ability of the cellular targets. These findings can explain the selective depletion of the CD16+ CD8+ subset that begins early in the in vivo HIV-1 infection.

Original languageEnglish
Pages (from-to)5879-5888
Number of pages10
JournalJournal of Virology
Volume67
Issue number10
Publication statusPublished - Oct 1993

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natural killer cells
interferons
Human immunodeficiency virus 1
Natural Killer Cells
Interferons
HIV-1
cytokines
Cytokines
Virus Replication
Tumor Necrosis Factor-alpha
interferon-alpha
tumor necrosis factors
Virus Diseases
blood cells
virus replication
interleukin-2
Interferon-alpha
infection
tumor necrosis factor-alpha
Interleukin-2

ASJC Scopus subject areas

  • Immunology

Cite this

Tóth, F., Mosborg-Petersen, P., Kiss, J., Aboagye-Mathiesen, G., Zdravkovic, M., Hager, H., & Ebbesen, P. (1993). Differential replication of human immunodeficiency virus type 1 in CD8- and CD8+ subsets of natural killer cells: Relationship to cytokine production pattern. Journal of Virology, 67(10), 5879-5888.

Differential replication of human immunodeficiency virus type 1 in CD8- and CD8+ subsets of natural killer cells : Relationship to cytokine production pattern. / Tóth, F.; Mosborg-Petersen, Peter; Kiss, Jolán; Aboagye-Mathiesen, George; Zdravkovic, Milan; Hager, Henrik; Ebbesen, Peter.

In: Journal of Virology, Vol. 67, No. 10, 10.1993, p. 5879-5888.

Research output: Contribution to journalArticle

Tóth, F, Mosborg-Petersen, P, Kiss, J, Aboagye-Mathiesen, G, Zdravkovic, M, Hager, H & Ebbesen, P 1993, 'Differential replication of human immunodeficiency virus type 1 in CD8- and CD8+ subsets of natural killer cells: Relationship to cytokine production pattern', Journal of Virology, vol. 67, no. 10, pp. 5879-5888.
Tóth, F. ; Mosborg-Petersen, Peter ; Kiss, Jolán ; Aboagye-Mathiesen, George ; Zdravkovic, Milan ; Hager, Henrik ; Ebbesen, Peter. / Differential replication of human immunodeficiency virus type 1 in CD8- and CD8+ subsets of natural killer cells : Relationship to cytokine production pattern. In: Journal of Virology. 1993 ; Vol. 67, No. 10. pp. 5879-5888.
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