Differential processing of prodynorphin and proenkephalin in specific regions of the rat brain

N. Zamir, E. Weber, M. Palkovits, M. Brownstein

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Prodynorphin-derived peptides [dynorphin A (Dyn A)-(1-17), Dyn A-(1-8), Dyn B, α-neo-endorphin, and β-neo-endorphin] and proenkephalin-derived peptides {[Leu]enkephalin ([Leu]Enk) and [Met]enkephalin-Arg6-Gly7-Leu8 ([Met]Enk-Arg-Gly-Leu)} in selected brain areas of the rat were measured by specific radioimmunoassays. We report here that different regions of rat brain contain strikingly different proportions of the prodynorphin and proenkephalin-derived peptides. There is a molar excess of α-neo-endorphin-derived peptides over Dyn B and Dyn A-derived peptides in many brain areas. [Leu]Enk concentrations exceed those of [Met]Enk-Arg-Gly-Leu in certain brain areas such as the substantia nigra, dentate gyrus, globus pallidus, and median eminence (area rich in dynorphin-related peptides). These results indicated that (i) there is differential processing of prodynorphin in different brain regions and (ii) [Leu]Enk may be derived from Dyn A or dyn B (or both). In certain brain regions [Leu]Enk may derive from two separate precursors (prodynorphin and proenkephalin) in two distinct neuronal systems.

Original languageEnglish
Pages (from-to)6886-6889
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number21 I
Publication statusPublished - 1984
Externally publishedYes

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