Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma

A. Rot, E. Schwarzinger, S. Szakáll, T. Radics, I. Vályi-Nagy, C. Kiss, Ildikó J. Márton

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

In situ distribution of three prototype chemokines interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1 and Rantes was determined in chronic human periapical granulomas by immunohistochemistry using monoclonal antibodies. IL-8 was found primarily in the cytoplasm of the Malassez epithelial cells. MCP-1 immunoreactivity was confined to the endothelial cells that lined small venules. Each of the three investigated chemokines, including Rantes, exhibited a characteristic binding pattern to the extracellular matrix of the lesion. The observed chemokines may play a role in establishing the cellular composition of chronic apical periodontitis, thus augmenting the intensity of local inflammation and tissue damage.

Original languageEnglish
Pages (from-to)63-65
Number of pages3
JournalOral microbiology and immunology
Volume15
Issue number1
DOIs
Publication statusPublished - Feb 1 2000

Keywords

  • Chemokines
  • Interleukin-8
  • Monocyte chemoattractant protein-1
  • Periapical granuloma
  • Rantes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Dentistry(all)
  • Microbiology (medical)

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