Differential HIV replication and HIV-induced interferon production in mononuclear phagocytes: relationship to cell maturation

P. Mosborg-Petersen, F. D. Toth, V. Zachar, J. A. Villadsen, N. Nørskov-Lauritsen, G. Aboagye-Mathiesen, J. C. Chermann, P. Ebbesen

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9 Citations (Scopus)

Abstract

We have investigated the replication of human immunodeficiency virus (HIV) and HIV-induced interferon (IFN) production in human mononuclear phagocytes at 2 different stages of in vitro maturation. Blood monocytes and monocyte-derived macrophages from 6 healthy, HIV-seronegative donors were challenged with HIV1IIIB and HIV2ROD. Freshly separated monocytes produced IFN when inoculated with both HIV types. In these cultures, an inverse correlation was observed between the amount of IFN production and the rate of HIV replication. In contrast to the monocytes, 5-day-old monocyte-derived macrophages did not produce IFN when challenged with HIV, but a significant replication of HIV1IIIB and HIV2ROD was found in all cultures.

Original languageEnglish
Pages (from-to)353-361
Number of pages9
JournalResearch in Virology
Volume142
Issue number5
DOIs
Publication statusPublished - 1991

Keywords

  • Correlation, Cell cultures, Stages
  • HIV1
  • HIV2, Monocyte, Macrophage, Interferon, Replication, Maturation

ASJC Scopus subject areas

  • Immunology
  • Virology

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    Mosborg-Petersen, P., Toth, F. D., Zachar, V., Villadsen, J. A., Nørskov-Lauritsen, N., Aboagye-Mathiesen, G., Chermann, J. C., & Ebbesen, P. (1991). Differential HIV replication and HIV-induced interferon production in mononuclear phagocytes: relationship to cell maturation. Research in Virology, 142(5), 353-361. https://doi.org/10.1016/0923-2516(91)90002-K