Differential excretion of xenobiotic acyl-esters of carnitine due to administration of pivampicillin and valproate

B. Melegh, J. Kerner, V. Jaszai, L. L. Bieber

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Abstract

The fate of supplemental carnitine was studied in human subjects treated with drugs known to cause carnitine deficiency. Six children were treated with pivampicillin and equimolar l-carnitine for 7 days. On the last day of treatment, the plasma levels of total and free carnitine were decreased, but acylcarnitine levels were increased. A 12-fold increase in urinary excretion of acylcarnitines was found; it increased from 188.5 ± 82.7 to 2218.4 ± 484.1 μmole/day, and 84% was pivaloylcarnitine. Free carnitine excretion was reduced. Ten epileptic children on chronic valproate treatment received equimolar carnitine for a 2-week period. Plasma carnitine levels were elevated on the last day of treatment. A 3.4-fold increase in urinary acylcarnitines was found, but most of the excreted carnitines were free (64.5-fold increases). These data show that pivalate is readily converted to carnitine esters, in contrast to the limited conversion of valproate to acylcarnitines in humans.

Original languageEnglish
Pages (from-to)30-38
Number of pages9
JournalBiochemical Medicine and Metabolic Biology
Volume43
Issue number1
DOIs
Publication statusPublished - Feb 1990

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry

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