Differential effects of cisterna magna cannulation on β-endorphin levels in rat plasma and cerebrospinal fluid

I. Barna, C. G J Sweep, H. D. Veldhuis, V. M. Wiegant

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The concentration of β-endorphin-like immunoreactivity (β-ELIR) was determined in plasma and cerebrospinal fluid (CSF) of rats at various times following the implantation under Hypnorm® anesthesia of a permanent cannula into the cisterna magna. Plasma β-ELIR levels were highly increased immediately after the operation, and gradually returned to basal within 6 h. The β-ELIR concentration in CSF followed a completely different pattern. It appeared to be rather stable during the first hour after the operation, was decreased at 2 h, and showed a marked increase 24 h after surgery. Two days after the surgery, β-ELIR levels in CSF had decreased to a stable basal level which was maintained for at least 7 days. When at this stage animals were treated with Hypnorm, plasma β-ELIR was again highly increased 30 min and not 24 h after injection, but no changes were found in the β-ELIR concentration in CSF. These data indicate that implantation of a cannula into the cisterna magna induces postoperative changes in the CSF levels of β-endorphin that are detectable up to at least 24 h later. Moreover, the lack of correlation between CSF and plasma levels of β-ELIR points towards differences in the regulation of brain and pituitary pro-opiomelanocortin cells.

Original languageEnglish
Pages (from-to)517-524
Number of pages8
JournalActa Endocrinologica
Volume117
Issue number4
Publication statusPublished - 1988

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Cisterna Magna
Endorphins
Catheterization
Cerebrospinal Fluid
Pro-Opiomelanocortin
Ambulatory Surgical Procedures
Anesthesia
Injections
Brain

ASJC Scopus subject areas

  • Endocrinology

Cite this

Differential effects of cisterna magna cannulation on β-endorphin levels in rat plasma and cerebrospinal fluid. / Barna, I.; Sweep, C. G J; Veldhuis, H. D.; Wiegant, V. M.

In: Acta Endocrinologica, Vol. 117, No. 4, 1988, p. 517-524.

Research output: Contribution to journalArticle

Barna, I. ; Sweep, C. G J ; Veldhuis, H. D. ; Wiegant, V. M. / Differential effects of cisterna magna cannulation on β-endorphin levels in rat plasma and cerebrospinal fluid. In: Acta Endocrinologica. 1988 ; Vol. 117, No. 4. pp. 517-524.
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