Differential effects of baro- and chemoreceptor activation on two sympathetic outflows

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It is known that the sympathetic system can be activated as a whole or differentially depending on the afferent signals. In chloralose anesthetized cats (70 mg/kg) sympathetic activity was recorded simultaneously from the vertebral nerve (VN) supplying skin and muscles of forearm and from the inferior cardiac nerve (CN). Stimulation of baroreceptors by inflating a balloon placed in the sinus greatly inhibited the activity of both VN and CN. On the other hand, activation of chemoreceptors at the carotid sinus or at the arch of aorta by injecting lobeline (0.1cc - 10 μg) or NaCN (0.1cc - 30 μg) increased VN activity while inhibiting that of CN. The degree of differential effect was different depending on the site of chemoreceptor activation (right or left carotid sinus or arch of aorta) and the site from which the maximal effect was evoked varied in the individual preparations. Weak electrical stimulation of buffer nerves in some cases produced a response characteristic of chemoreceptor activation in others the effect was that of baroreceptor activation due probably to differences in the proportions of the two afferent fibers. The differential effect on the two sympathetic outflows was abolished by anemic decerebration indicating a role of supramedullary centers in differentiation. (Supported by USPHS grant NS-00814 and grant from The New York Heart Assoc. Inc.)

Original languageEnglish
Pages (from-to)No. 1488
JournalFederation Proceedings
Issue number3
Publication statusPublished - Jan 1 1977


ASJC Scopus subject areas

  • Medicine(all)

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