Differential effect of low molecular weight alcohols on the Con A stimulation of mouse spleen cells

Astrid Raile, Klaus P. Hammann, Otto Scheiner, Thomas Schulz, A. Erdei, Manfred P. Dierich

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Incorporation of [3H]thymidine ([3H]TdR) into concanavalin A (Con A)-stimulated murine splenocytes was found to be enhanced by addition of certain concentrations of ethanol, 2-propanol and acetone. The alcohol/acetone-induced enhancement of the Con A response was found to be accompanied by an increase of the percentage of living cells as assessed by trypan blue exclusion. Concentrations of ethanol and 2-propanol which caused maximum [3H]TdR uptake in Con A cultures were also found to lead to higher percentages of aggregated cells than in comparison to Con A cultures without alcohol. The data suggest that alcohols in certain concentrations are capable to achieve optimum Con A stimulation.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalImmunology Letters
Volume4
Issue number6
DOIs
Publication statusPublished - 1982

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Concanavalin A
Spleen
Molecular Weight
Alcohols
2-Propanol
Acetone
Ethanol
Trypan Blue
Thymidine

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Differential effect of low molecular weight alcohols on the Con A stimulation of mouse spleen cells. / Raile, Astrid; Hammann, Klaus P.; Scheiner, Otto; Schulz, Thomas; Erdei, A.; Dierich, Manfred P.

In: Immunology Letters, Vol. 4, No. 6, 1982, p. 305-309.

Research output: Contribution to journalArticle

Raile, Astrid ; Hammann, Klaus P. ; Scheiner, Otto ; Schulz, Thomas ; Erdei, A. ; Dierich, Manfred P. / Differential effect of low molecular weight alcohols on the Con A stimulation of mouse spleen cells. In: Immunology Letters. 1982 ; Vol. 4, No. 6. pp. 305-309.
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