Differential effect of corticosteroids on serum cystatin C in thrombocytopenic purpura and leukemia

Edit Bardi, Éva Dobos, János Kappelmayer, Csongor Kiss

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The aim of our study was to evaluate the influence of steroid therapy on serum cystatin C (cysC) concentrations in patients with acute lymphoblastic leukemia (ALL) and idiopthiás thrombocytopenias purpura (ITP). We studied 17 patients with ITP (girls: boys = 5:12, mean age: 7.6 yrs, range between 1 to 17 years) and 18 patients with ALL (girls: boys = 6:12, mean age: 6.3 yrs, range between 2 to 17 years). CysC and white blood cell count (WBC) in both group of patients were determined before and after 300 mg/m2 cumulative dose of steroid therapy. Corticosteroids increased the level of cysC in both groups of patients, however significant increase was found only in ITP patients between pre- and posttreatment values (0,96 ± 0,27 mg/L vs. 1,16 ± 0,3 mg/L, p = 0,02). Pretreatment cysC concentrations were within the reference range in patients with ITP but not with ALL and were significantly higher in ALL patients, than in ITP patients (1,23 ± 1,12 mg/L vs. 0,96 ± 0,27 mg/L, p = 0,02). Pretreatment WBC of ALL patients were significantly higher than of ITP patients (22,58 G/L, min. 3,5 G/L, max. 102,1 G/L vs. 7,46 G/L, min. 4,8 G/L, max. 12,3 G/L, p = 0.03). We have found significant correlation between pretreatment cysC and WBC values in ALL patients (p = 0.04). Although the concentration of cysC may be slightly and reversibly influenced by corticosteroid treatment, cysC is sensitive to detect early and moderate deteoriantation of GFR in children with cancer.

Original languageEnglish
Pages (from-to)453-456
Number of pages4
JournalPathology and Oncology Research
Volume16
Issue number3
DOIs
Publication statusPublished - Sep 1 2010

Keywords

  • Acute lymphoblastic leukemia
  • Coricosteroid therapy
  • Cystatin C
  • Glomerular function
  • Idiopathic thrombocytopenic purpura
  • Leukemic cell burden

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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