Differential cytokine pattern in the exhaled breath of patients with lung cancer

Tamás Kullmann, I. Barta, Eszter Csiszé, B. Antus, I. Horváth

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Tumour cells may alter the protein pattern of biological samples resulting in specific differences that may aid diagnosis and treatment. In this pilot study we tested the cytokine pattern of exhaled breath condensate of patients with lung cancer. Breath condensates collected from 50 smoking patients with lung cancer and 25 smokers without clinical or radiological sign of a pulmonary tumour but having co-morbidities with similar severity as those with lung cancer were pooled for antibody microarray analysis testing 120 cytokines in parallel. Every cytokine on the array gave a signal in both groups. Nine cytokines including eotaxin, FGFs, IL-10 and MIP-3 were present with more than two-fold difference between the two groups. Large number of cytokines is present in the exhaled breath. Further analysis of specific differences associated with lung cancer may have clinical importance.

Original languageEnglish
Pages (from-to)481-483
Number of pages3
JournalPathology and Oncology Research
Volume14
Issue number4
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Lung Neoplasms
Cytokines
Microarray Analysis
Interleukin-10
Neoplasms
Smoking
Morbidity
Lung
Antibodies
Proteins
Therapeutics

Keywords

  • Biomarker
  • Exhaled breath condensate
  • Lung cancer
  • Microarray
  • Proteomics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Differential cytokine pattern in the exhaled breath of patients with lung cancer. / Kullmann, Tamás; Barta, I.; Csiszé, Eszter; Antus, B.; Horváth, I.

In: Pathology and Oncology Research, Vol. 14, No. 4, 12.2008, p. 481-483.

Research output: Contribution to journalArticle

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