Differential binding activity of EA receptor bearing human lymphocyte subpopulations

K. Meretey, A. Falus, U. Boehm, S. Bozsoky

Research output: Contribution to journalArticle

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Abstract

Two types of EA rosettes were studied in rheumatoid arthritis patients and control subjects. Heterologous (rabbit) and homologous (anti-D) antibody sensitized human red blood cells (EA(r) and EA(h), respectively) were used for examining the EA binding capacity of human lymphocytes. Both control and rheumatoid arthritis blood samples yielded significantly lower EA(r)RFC levels as compared to the percentage of EA(h)RFCs, the difference being even more expressed with control lymphocytes. No difference, however, was observed in the case of tonsillar lymphocytes, as equal rosette levels were reached in both systems used. Introduction of immunosuppressive therapy resulted in a temporary dissociation of the two rosette values EA(r) and EA(h) binding lymphocytes were differently affected by aggregated human IgG, only the latter ones being inhibited, contrasting with the equal inhibitory action of purified Fc fragments. Reducing the density of anti-D antibodies on the surface of erythrocytes, the EA(h) rosette count dropped to the level of EA(r) RFCs. The data suggest an activity-depending Fc receptor distribution resulting in different binding capacity for more or less sensitized indicator RBCs.

Original languageEnglish
Pages (from-to)176-184
Number of pages9
JournalAllergie und Immunologie
Volume23
Issue number3
Publication statusPublished - 1977

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Lymphocyte Subsets
Lymphocytes
Anti-Idiotypic Antibodies
Rheumatoid Arthritis
Erythrocytes
Immunoglobulin Fc Fragments
Fc Receptors
Immunosuppressive Agents
Immunoglobulin G
Rabbits
RHO(D) antibody
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Differential binding activity of EA receptor bearing human lymphocyte subpopulations. / Meretey, K.; Falus, A.; Boehm, U.; Bozsoky, S.

In: Allergie und Immunologie, Vol. 23, No. 3, 1977, p. 176-184.

Research output: Contribution to journalArticle

Meretey, K. ; Falus, A. ; Boehm, U. ; Bozsoky, S. / Differential binding activity of EA receptor bearing human lymphocyte subpopulations. In: Allergie und Immunologie. 1977 ; Vol. 23, No. 3. pp. 176-184.
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