Different sequence environments of cysteines and half cystines in proteins Application to predict disulfide forming residues

András Fiser, Miklós Cserzö, Éva Tüdös, I. Simon

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Protein sequences are often derived by translating genetic information, rather than by classical protein sequencing. At the DNA level cysteines and half cystines are indistinguishable. Here we show that the sequential environments of 'free' cysteine and half cystine are different. A possible origin of this difference is discussed and a simple method to predict cysteines and half cystines from the amino acid sequence is also presented.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalFEBS Letters
Volume302
Issue number2
DOIs
Publication statusPublished - May 11 1992

Fingerprint

Disulfides
Cysteine
Proteins
Protein Sequence Analysis
Amino Acid Sequence
Amino Acids
DNA

Keywords

  • Free cysteine
  • Half cystine
  • Prediction
  • Sequential environment

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Different sequence environments of cysteines and half cystines in proteins Application to predict disulfide forming residues. / Fiser, András; Cserzö, Miklós; Tüdös, Éva; Simon, I.

In: FEBS Letters, Vol. 302, No. 2, 11.05.1992, p. 117-120.

Research output: Contribution to journalArticle

@article{4ea334f685464d549ffcfc3e7d589893,
title = "Different sequence environments of cysteines and half cystines in proteins Application to predict disulfide forming residues",
abstract = "Protein sequences are often derived by translating genetic information, rather than by classical protein sequencing. At the DNA level cysteines and half cystines are indistinguishable. Here we show that the sequential environments of 'free' cysteine and half cystine are different. A possible origin of this difference is discussed and a simple method to predict cysteines and half cystines from the amino acid sequence is also presented.",
keywords = "Free cysteine, Half cystine, Prediction, Sequential environment",
author = "Andr{\'a}s Fiser and Mikl{\'o}s Cserz{\"o} and {\'E}va T{\"u}d{\"o}s and I. Simon",
year = "1992",
month = "5",
day = "11",
doi = "10.1016/0014-5793(92)80419-H",
language = "English",
volume = "302",
pages = "117--120",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Different sequence environments of cysteines and half cystines in proteins Application to predict disulfide forming residues

AU - Fiser, András

AU - Cserzö, Miklós

AU - Tüdös, Éva

AU - Simon, I.

PY - 1992/5/11

Y1 - 1992/5/11

N2 - Protein sequences are often derived by translating genetic information, rather than by classical protein sequencing. At the DNA level cysteines and half cystines are indistinguishable. Here we show that the sequential environments of 'free' cysteine and half cystine are different. A possible origin of this difference is discussed and a simple method to predict cysteines and half cystines from the amino acid sequence is also presented.

AB - Protein sequences are often derived by translating genetic information, rather than by classical protein sequencing. At the DNA level cysteines and half cystines are indistinguishable. Here we show that the sequential environments of 'free' cysteine and half cystine are different. A possible origin of this difference is discussed and a simple method to predict cysteines and half cystines from the amino acid sequence is also presented.

KW - Free cysteine

KW - Half cystine

KW - Prediction

KW - Sequential environment

UR - http://www.scopus.com/inward/record.url?scp=0026579140&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026579140&partnerID=8YFLogxK

U2 - 10.1016/0014-5793(92)80419-H

DO - 10.1016/0014-5793(92)80419-H

M3 - Article

C2 - 1633841

AN - SCOPUS:0026579140

VL - 302

SP - 117

EP - 120

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 2

ER -