Different patterns of auditory information processing deficits in chronic schizophrenia and bipolar disorder with psychotic features

Nóra Domján, Gábor Csifcsák, Gergely Drótos, Z. Janka, István Szendi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

With the development of DSM-V and ICD-11 the definitions of psychiatric disorders are under re-evaluation. The emphasis is shifted from distinct disorders to clusters defined not only by symptomatology, but also by underlying neurobiology and cognitive deficits. Bipolar disorder I (BD-I) and schizophrenia (SZ) are of special interest since their differential diagnosis is often problematic and they partially overlap in measures ranging from genetics to neurophysiology. Event-related potentials (ERPs) are one of the most studied factors but the results are still controversial, primarily in BD-I, where ERPs reflecting different stages of auditory information processing have been much less investigated. In this study, we aimed at investigating the changes of five auditory event-related potentials (P50 and N100 suppression, duration and pitch deviant mismatch negativity (MMN) and P3b) in 20 SZ and 20 BD-I patients with a history of psychosis and 21 healthy control subjects. Our data revealed substantial differences between the two patient groups. Only patients with SZ demonstrated impaired N100 suppression, shorter duration deviant MMN latency and attenuated P3b amplitude, while prolonged pitch deviant MMN latency was found to be characteristic of the BD-I group. No shared ERP abnormalities were observed among the patient groups. Our results indicate that SZ and BD-I are characterized by highly different neurophysiological profiles when measured in the same laboratory setting.

Original languageEnglish
Pages (from-to)253-259
Number of pages7
JournalSchizophrenia Research
Volume139
Issue number1-3
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Schizophrenia Spectrum and Other Psychotic Disorders
Automatic Data Processing
Bipolar Disorder
Evoked Potentials
Schizophrenia
Neurophysiology
Neurobiology
Diagnostic and Statistical Manual of Mental Disorders
Psychotic Disorders
Psychiatry
Healthy Volunteers
Differential Diagnosis

Keywords

  • Bipolar disorder
  • Mismatch negativity
  • N100
  • P3b
  • P50
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Different patterns of auditory information processing deficits in chronic schizophrenia and bipolar disorder with psychotic features. / Domján, Nóra; Csifcsák, Gábor; Drótos, Gergely; Janka, Z.; Szendi, István.

In: Schizophrenia Research, Vol. 139, No. 1-3, 08.2012, p. 253-259.

Research output: Contribution to journalArticle

Domján, Nóra ; Csifcsák, Gábor ; Drótos, Gergely ; Janka, Z. ; Szendi, István. / Different patterns of auditory information processing deficits in chronic schizophrenia and bipolar disorder with psychotic features. In: Schizophrenia Research. 2012 ; Vol. 139, No. 1-3. pp. 253-259.
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