Different inflammatory biomarker patterns in the cerebro-spinal fluid following heart surgery and major non-cardiac operations

Helton J. Reis, Antonio L. Teixeira, János Kálmán, Gábor Bogáts, Barna Babik, Zoltán Janka, Mauro M. Teixeira, Palotás András

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11 Citations (Scopus)


Cognitive decline occurs frequently after cardiac surgery and it may lead to patient morbidity. The purpose of this study is to focus on the static incidence of neuro-psychiatric impairment associated with altered inflammatory biomarkers in the cerebro-spinal fluid (CSF) that may provide an insight into the mechanisms of acute peri-operative cognitive disturbances related to heart surgery. Immunoassays were used to evaluate concentrations of several cytokines in CSF of patients undergoing either off-pump coronary artery bypass grafting (OP-CABG) or major non-cardiac surgeries. Inter-group analysis showed no differences in baseline cytokine abundance. Levels of IL-8 have markedly increased both after OP-CABG and major non-cardiac surgeries (34.59±7.15 vs. 99.45±6.35, and 27.44±7.17 vs. 66.63±15.18). Rantes showed significantly greater quantity in CSF of the non-cardiac group after surgery (8.71±3.37 vs. 114.56±65.42), whereas it became somewhat less abundant in the post-operative period but statistically unchanged in the OP-CABG cohort (19.87±15.71 vs. 9.37±3.65). IP-10 and MCP-1 did not show significant changes in their concentrations in either patient population (OP-CABG: 254.41±160.01 vs. 224.55±214.39, and 140.37±40.98 vs. 147.16±37.98; non-cardiac: 274.99±219.44 vs. 395.09±468.30, and 126.56±31.24 vs. 124.41±49.89, respectively). These findings suggest that cardiac surgery provokes alterations in the levels of various cytokines in the CSF, and the OP-CABG induced changes in biomarker profile differs from that seen after major non-cardiac surgeries. This, along with other biomarkers, may offer an explanation for relationships between the pronounced incidence of cognitive impairment after heart operations.

Original languageEnglish
Pages (from-to)639-642
Number of pages4
JournalCurrent Drug Metabolism
Issue number6
Publication statusPublished - Aug 1 2007



  • Alzheimer's disease
  • Atherosclerosis
  • Biomarker
  • Cardiac surgery
  • Cerebrospinal fluid
  • Cognitive function
  • Coronary heart disease
  • Cytokine
  • Major non-cardiac surgery
  • Post-operative Alzheimer's disease
  • Post-operative neurologic complication

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry

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