Different inflammatory biomarker patterns in the cerebro-spinal fluid following heart surgery and major non-cardiac operations

Helton J. Reis, Antonio L. Teixeira, J. Kálmán, G. Bogáts, Barna Babik, Z. Janka, Mauro M. Teixeira, Palotás András

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cognitive decline occurs frequently after cardiac surgery and it may lead to patient morbidity. The purpose of this study is to focus on the static incidence of neuro-psychiatric impairment associated with altered inflammatory biomarkers in the cerebro-spinal fluid (CSF) that may provide an insight into the mechanisms of acute peri-operative cognitive disturbances related to heart surgery. Immunoassays were used to evaluate concentrations of several cytokines in CSF of patients undergoing either off-pump coronary artery bypass grafting (OP-CABG) or major non-cardiac surgeries. Inter-group analysis showed no differences in baseline cytokine abundance. Levels of IL-8 have markedly increased both after OP-CABG and major non-cardiac surgeries (34.59±7.15 vs. 99.45±6.35, and 27.44±7.17 vs. 66.63±15.18). Rantes showed significantly greater quantity in CSF of the non-cardiac group after surgery (8.71±3.37 vs. 114.56±65.42), whereas it became somewhat less abundant in the post-operative period but statistically unchanged in the OP-CABG cohort (19.87±15.71 vs. 9.37±3.65). IP-10 and MCP-1 did not show significant changes in their concentrations in either patient population (OP-CABG: 254.41±160.01 vs. 224.55±214.39, and 140.37±40.98 vs. 147.16±37.98; non-cardiac: 274.99±219.44 vs. 395.09±468.30, and 126.56±31.24 vs. 124.41±49.89, respectively). These findings suggest that cardiac surgery provokes alterations in the levels of various cytokines in the CSF, and the OP-CABG induced changes in biomarker profile differs from that seen after major non-cardiac surgeries. This, along with other biomarkers, may offer an explanation for relationships between the pronounced incidence of cognitive impairment after heart operations.

Original languageEnglish
Pages (from-to)639-642
Number of pages4
JournalCurrent Drug Metabolism
Volume8
Issue number6
DOIs
Publication statusPublished - Aug 2007

Fingerprint

Off-Pump Coronary Artery Bypass
Biomarkers
Coronary Artery Bypass
Surgery
Thoracic Surgery
Cerebrospinal Fluid
Fluids
Pumps
Cytokines
Incidence
Interleukin-8
Immunoassay
Psychiatry
Morbidity
Population

Keywords

  • Alzheimer's disease
  • Atherosclerosis
  • Biomarker
  • Cardiac surgery
  • Cerebrospinal fluid
  • Cognitive function
  • Coronary heart disease
  • Cytokine
  • Major non-cardiac surgery
  • Post-operative Alzheimer's disease
  • Post-operative neurologic complication

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Different inflammatory biomarker patterns in the cerebro-spinal fluid following heart surgery and major non-cardiac operations. / Reis, Helton J.; Teixeira, Antonio L.; Kálmán, J.; Bogáts, G.; Babik, Barna; Janka, Z.; Teixeira, Mauro M.; András, Palotás.

In: Current Drug Metabolism, Vol. 8, No. 6, 08.2007, p. 639-642.

Research output: Contribution to journalArticle

Reis, Helton J. ; Teixeira, Antonio L. ; Kálmán, J. ; Bogáts, G. ; Babik, Barna ; Janka, Z. ; Teixeira, Mauro M. ; András, Palotás. / Different inflammatory biomarker patterns in the cerebro-spinal fluid following heart surgery and major non-cardiac operations. In: Current Drug Metabolism. 2007 ; Vol. 8, No. 6. pp. 639-642.
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