Different H2 receptor antihistamines dissimilarly retard the growth of xenografted human melanoma cells in immunodeficient mice

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17 Citations (Scopus)

Abstract

Melanoma cells and tissues contain considerable amounts of histamine and express histamine receptors, suggesting the existence of autocrine and paracrine regulation by histamine. Our previous in vitro results suggested that histamine elevates melanoma cell growth through the H2 receptor. In this work we show that in vivo tumour proliferation in immunodeficient mice xenotransplanted with a human melanoma cell line is diminished by cimetidine, an H2 receptor antagonist, if combined with a tamoxifen derivate acting on cytochrome p450 molecules (DPPE). Ranitidine, another H2 receptor antagonist, has a weaker inhibitory effect, the kinetics and mechanism of which is probably dissimilar to that of the cimetidine/DPPE mixture.

Original languageEnglish
Pages (from-to)833-836
Number of pages4
JournalCell Biology International
Volume26
Issue number9
DOIs
Publication statusPublished - 2002

Fingerprint

Histamine H2 Receptors
Histamine Antagonists
Histamine
Melanoma
Cimetidine
Growth
Histamine Receptors
Ranitidine
Tamoxifen
Cytochrome P-450 Enzyme System
Cell Line
Neoplasms
1,2-dipalmitoyl-3-phosphatidylethanolamine

Keywords

  • Histamine
  • Histamine antagonists
  • Melanoma
  • Tumour Growth

ASJC Scopus subject areas

  • Cell Biology

Cite this

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title = "Different H2 receptor antihistamines dissimilarly retard the growth of xenografted human melanoma cells in immunodeficient mice",
abstract = "Melanoma cells and tissues contain considerable amounts of histamine and express histamine receptors, suggesting the existence of autocrine and paracrine regulation by histamine. Our previous in vitro results suggested that histamine elevates melanoma cell growth through the H2 receptor. In this work we show that in vivo tumour proliferation in immunodeficient mice xenotransplanted with a human melanoma cell line is diminished by cimetidine, an H2 receptor antagonist, if combined with a tamoxifen derivate acting on cytochrome p450 molecules (DPPE). Ranitidine, another H2 receptor antagonist, has a weaker inhibitory effect, the kinetics and mechanism of which is probably dissimilar to that of the cimetidine/DPPE mixture.",
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AU - Szincsák, Nora

AU - Hegyesi, H.

AU - Hunyadi, J.

AU - Falus, A.

AU - Juhász, I.

PY - 2002

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AB - Melanoma cells and tissues contain considerable amounts of histamine and express histamine receptors, suggesting the existence of autocrine and paracrine regulation by histamine. Our previous in vitro results suggested that histamine elevates melanoma cell growth through the H2 receptor. In this work we show that in vivo tumour proliferation in immunodeficient mice xenotransplanted with a human melanoma cell line is diminished by cimetidine, an H2 receptor antagonist, if combined with a tamoxifen derivate acting on cytochrome p450 molecules (DPPE). Ranitidine, another H2 receptor antagonist, has a weaker inhibitory effect, the kinetics and mechanism of which is probably dissimilar to that of the cimetidine/DPPE mixture.

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