Different effect of hyperglycemia on stroke outcome in non-diabetic and diabetic patients - a cohort study

Judit Zsuga, R. Gesztelyi, Adam Kemeny-Beke, Klara Fekete, Laszlo Mihalka, Szabomonika Adrienn, Laszlo Kardos, L. Csiba, D. Bereczki

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives: Relationship between hyperglycemia and stroke outcome is unclear, partly due to the small sample size in most studies, and partly due to lack of consensus concerning the cutoff level for hyperglycemia. Methods: In a cohort study, we investigated whether on-admission hyperglycemia is an independent predictor for 30-day case fatality by analyzing data of 2496 consecutive computed tomography (CT) verified acute ischemic stroke patients (2077 non-diabetic and 419 diabetic) included in the prospective, hospital-based Debrecen Stroke Database. Instead of using an arbitrary cutoff level for hyperglycemia, quartiles of on-admission glucose level were used for Kaplan-Meier survival curves and Cox proportional hazard modeling. Results: The four quartiles of serum glucose level were in the range as follows: 7.501 mmol/l (n5664, 618, 597, and 617, respectively). Among all 2496 participants, the adjusted hazard ratios for death increased with each quartile of admission glucose 1.96 [95% confidence interval (CI): 1.07-3.60; P50.03], 1.56 (95% CI: 0.83-2.94; P50.17), and 3.04 (95% CI: 1.70-5.44; P

Original languageEnglish
Pages (from-to)72-79
Number of pages8
JournalNeurological Research
Volume34
Issue number1
DOIs
Publication statusPublished - Jan 2012

Fingerprint

Hyperglycemia
Cohort Studies
Stroke
Confidence Intervals
Glucose
Kaplan-Meier Estimate
Sample Size
Tomography
Databases
Serum

Keywords

  • Diabetes mellitus
  • Hyperglycemia
  • Ischemic stroke
  • Stroke
  • Survival

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Different effect of hyperglycemia on stroke outcome in non-diabetic and diabetic patients - a cohort study. / Zsuga, Judit; Gesztelyi, R.; Kemeny-Beke, Adam; Fekete, Klara; Mihalka, Laszlo; Adrienn, Szabomonika; Kardos, Laszlo; Csiba, L.; Bereczki, D.

In: Neurological Research, Vol. 34, No. 1, 01.2012, p. 72-79.

Research output: Contribution to journalArticle

Zsuga, Judit ; Gesztelyi, R. ; Kemeny-Beke, Adam ; Fekete, Klara ; Mihalka, Laszlo ; Adrienn, Szabomonika ; Kardos, Laszlo ; Csiba, L. ; Bereczki, D. / Different effect of hyperglycemia on stroke outcome in non-diabetic and diabetic patients - a cohort study. In: Neurological Research. 2012 ; Vol. 34, No. 1. pp. 72-79.
@article{8b132dd73cf04a9d8189ce18a1b2a984,
title = "Different effect of hyperglycemia on stroke outcome in non-diabetic and diabetic patients - a cohort study",
abstract = "Objectives: Relationship between hyperglycemia and stroke outcome is unclear, partly due to the small sample size in most studies, and partly due to lack of consensus concerning the cutoff level for hyperglycemia. Methods: In a cohort study, we investigated whether on-admission hyperglycemia is an independent predictor for 30-day case fatality by analyzing data of 2496 consecutive computed tomography (CT) verified acute ischemic stroke patients (2077 non-diabetic and 419 diabetic) included in the prospective, hospital-based Debrecen Stroke Database. Instead of using an arbitrary cutoff level for hyperglycemia, quartiles of on-admission glucose level were used for Kaplan-Meier survival curves and Cox proportional hazard modeling. Results: The four quartiles of serum glucose level were in the range as follows: 7.501 mmol/l (n5664, 618, 597, and 617, respectively). Among all 2496 participants, the adjusted hazard ratios for death increased with each quartile of admission glucose 1.96 [95{\%} confidence interval (CI): 1.07-3.60; P50.03], 1.56 (95{\%} CI: 0.83-2.94; P50.17), and 3.04 (95{\%} CI: 1.70-5.44; P",
keywords = "Diabetes mellitus, Hyperglycemia, Ischemic stroke, Stroke, Survival",
author = "Judit Zsuga and R. Gesztelyi and Adam Kemeny-Beke and Klara Fekete and Laszlo Mihalka and Szabomonika Adrienn and Laszlo Kardos and L. Csiba and D. Bereczki",
year = "2012",
month = "1",
doi = "10.1179/1743132811Y.0000000062",
language = "English",
volume = "34",
pages = "72--79",
journal = "Neurological Research",
issn = "0161-6412",
publisher = "Maney Publishing",
number = "1",

}

TY - JOUR

T1 - Different effect of hyperglycemia on stroke outcome in non-diabetic and diabetic patients - a cohort study

AU - Zsuga, Judit

AU - Gesztelyi, R.

AU - Kemeny-Beke, Adam

AU - Fekete, Klara

AU - Mihalka, Laszlo

AU - Adrienn, Szabomonika

AU - Kardos, Laszlo

AU - Csiba, L.

AU - Bereczki, D.

PY - 2012/1

Y1 - 2012/1

N2 - Objectives: Relationship between hyperglycemia and stroke outcome is unclear, partly due to the small sample size in most studies, and partly due to lack of consensus concerning the cutoff level for hyperglycemia. Methods: In a cohort study, we investigated whether on-admission hyperglycemia is an independent predictor for 30-day case fatality by analyzing data of 2496 consecutive computed tomography (CT) verified acute ischemic stroke patients (2077 non-diabetic and 419 diabetic) included in the prospective, hospital-based Debrecen Stroke Database. Instead of using an arbitrary cutoff level for hyperglycemia, quartiles of on-admission glucose level were used for Kaplan-Meier survival curves and Cox proportional hazard modeling. Results: The four quartiles of serum glucose level were in the range as follows: 7.501 mmol/l (n5664, 618, 597, and 617, respectively). Among all 2496 participants, the adjusted hazard ratios for death increased with each quartile of admission glucose 1.96 [95% confidence interval (CI): 1.07-3.60; P50.03], 1.56 (95% CI: 0.83-2.94; P50.17), and 3.04 (95% CI: 1.70-5.44; P

AB - Objectives: Relationship between hyperglycemia and stroke outcome is unclear, partly due to the small sample size in most studies, and partly due to lack of consensus concerning the cutoff level for hyperglycemia. Methods: In a cohort study, we investigated whether on-admission hyperglycemia is an independent predictor for 30-day case fatality by analyzing data of 2496 consecutive computed tomography (CT) verified acute ischemic stroke patients (2077 non-diabetic and 419 diabetic) included in the prospective, hospital-based Debrecen Stroke Database. Instead of using an arbitrary cutoff level for hyperglycemia, quartiles of on-admission glucose level were used for Kaplan-Meier survival curves and Cox proportional hazard modeling. Results: The four quartiles of serum glucose level were in the range as follows: 7.501 mmol/l (n5664, 618, 597, and 617, respectively). Among all 2496 participants, the adjusted hazard ratios for death increased with each quartile of admission glucose 1.96 [95% confidence interval (CI): 1.07-3.60; P50.03], 1.56 (95% CI: 0.83-2.94; P50.17), and 3.04 (95% CI: 1.70-5.44; P

KW - Diabetes mellitus

KW - Hyperglycemia

KW - Ischemic stroke

KW - Stroke

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=84855162468&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855162468&partnerID=8YFLogxK

U2 - 10.1179/1743132811Y.0000000062

DO - 10.1179/1743132811Y.0000000062

M3 - Article

VL - 34

SP - 72

EP - 79

JO - Neurological Research

JF - Neurological Research

SN - 0161-6412

IS - 1

ER -