Different anticancer effects of fluvastatin on primary hepatocellular tumors and metastases in rats

György Paragh, Gabriella Fóris, György Paragh, Ildikó Seres, Zsolt Karányi, Péter Fülöp, Zoltán Balogh, Béla Kosztáczky, Farkas Teichmann, Pál Kertai

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Rats (FLF1) were pretreated with 2 and 20 mg/kg/day fluvastatin (Flu), and after 6 weeks, hepatocellular tumor cells were inoculated under the left renal capsule. At different times, growth and pyruvate kinase (PK) activity of the primary tumors and lymph node metastases were determined. Flu had a dose-dependent inhibitory effect on primary and metastatic tumors, and the inhibitiory effect on growth and PK activity in metastases were higher than in primary tumors. Finally, Flu had an earlier inhibitory effect on the early appeared PK activity in metastases than in primary tumors.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalCancer Letters
Volume222
Issue number1
DOIs
Publication statusPublished - May 10 2005

Keywords

  • Fluvastatin
  • Hepatocarcinoma
  • Metastasis
  • Pyruvate kinase
  • Rat
  • Tumor growth inhibition

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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