Capacity to consume homologous and heterologous (human or guinea pig) complement of aggregated rat myeloma proteins belonging to different IgG subclasses was studied. In the homologous system, complement consumption was observed with all the 4 subclasses (IgG1, IgG2a, IgG2b, IgG2c), while in human serum, IgG2c, and in guinea pig serum, IgG1 totally failed to consume complement. IgG1, IgG2a and IgG2c aggregates consumed rat complement through the classical pathway, while IgG2b proteins were able to trigger both main complement pathways.
ASJC Scopus subject areas
- Immunology and Allergy