Dietary restriction increases site-specific histone H3 acetylation in rat liver: Possible modulation by sirtuins

Kyojiro Kawakami, Akihiro Nakamura, S. Goto

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We studied dietary restriction (DR) related changes of site-specific acetylation of histone H3 in rat livers to explore a possible link to histone modifications and sirtuin levels with anti-aging effects of DR. The acetylation at lysine residue 9, 27 and 56 in H3 was 20-30% higher in DR animals compared with ad libitum fed counterparts. SIRT6, one of histone deacetylases, was significantly decreased by DR and thereby may be involved in an increase in the histone acetylation. Our findings suggest that upregulation of chromatin activities through increased histone acetylation is a mechanism of anti-aging effects of DR.

Original languageEnglish
Pages (from-to)836-840
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume418
Issue number4
DOIs
Publication statusPublished - Feb 24 2012

Fingerprint

Sirtuins
Acetylation
Liver
Histones
Rats
Modulation
Histone Code
Aging of materials
Histone Deacetylases
Lysine
Chromatin
Animals
Up-Regulation

Keywords

  • Acetylation
  • Aging
  • Dietary (calorie) restriction
  • Epigenetics
  • Histone modification
  • Sirtuin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Dietary restriction increases site-specific histone H3 acetylation in rat liver : Possible modulation by sirtuins. / Kawakami, Kyojiro; Nakamura, Akihiro; Goto, S.

In: Biochemical and Biophysical Research Communications, Vol. 418, No. 4, 24.02.2012, p. 836-840.

Research output: Contribution to journalArticle

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