Dietary and lifestyle quality indices with/without physical activity and markers of insulin resistance in European adolescents: The HELENA study

David Jiménez-Pavón, Maria A. Sesé, Inge Huybrechts, Magdalena Cuenca-García, Gonzalo Palacios, Jonatan R. Ruiz, Christina Breidenassel, Catherine Leclercq, Laurent Beghin, Maria Plada, Yannis Manios, Odysseas Androutsos, Jean Dallongeville, Anthony Kafatos, Kurt Widhalm, Dénes Molnar, Luis A. Moreno

Research output: Contribution to journalArticle

16 Citations (Scopus)


Emerging data indicate that higher levels of insulin resistance (IR) are common among children and adolescents and are related to cardiometabolic risk; therefore, IR requires consideration early in life. In addition, there is a lack of conclusive evidence regarding the role of dietary nutrients on IR. The Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study (HELENA-CSS) was conducted in European adolescents aged 12·5-17·5 years. A total of 637 participants with valid homeostasis model assessment (HOMA) index data and who completed at least a 2Â d 24Â h dietary recall were included in the study (60Â % of the total HELENA-CSS sample). There were two dietary indices calculated, with the only difference between them being the inclusion or not of physical activity (PA). Markers of IR such as HOMA and the quantitative insulin sensitivity check index (QUICKI) were calculated. Pubertal status, BMI and cardiorespiratory fitness (CRF) were measured as potential confounders. The dietary index including PA was inversely associated with HOMA and directly with the QUICKI in females, but not in males, after adjusting for pubertal status, centre, BMI and CRF. In conclusion, the present study indicates that considering PA as part of the dietary index is of relevance as the resulted index is inversely related to IR independently of potential confounders including CRF. Overall, these findings suggest that intervention studies aimed at preventing IR in young people should focus on increasing the quality of the diet and also on including an optimal PA level in healthy adolescents.

Original languageEnglish
Pages (from-to)1919-1925
Number of pages7
JournalBritish Journal of Nutrition
Issue number10
Publication statusPublished - Nov 28 2013



  • Adolescents
  • Diet quality index
  • Insulin resistance
  • Physical activity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Jiménez-Pavón, D., Sesé, M. A., Huybrechts, I., Cuenca-García, M., Palacios, G., Ruiz, J. R., Breidenassel, C., Leclercq, C., Beghin, L., Plada, M., Manios, Y., Androutsos, O., Dallongeville, J., Kafatos, A., Widhalm, K., Molnar, D., & Moreno, L. A. (2013). Dietary and lifestyle quality indices with/without physical activity and markers of insulin resistance in European adolescents: The HELENA study. British Journal of Nutrition, 110(10), 1919-1925.